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DOI10.3899/jrheum.100652
Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients
Bang, So-Young1; Kim, Tae-Hwan1; Lee, Bitnara1; Kwon, Eunji1; Choi, Sang Hyun2; Lee, Ki Soo4; Shim, Seung Cheol3; Pope, Angela7; Rahman, Proton6; Reveille, John D.5; Inman, Robert D.8
通讯作者Kim, Tae-Hwan
来源期刊JOURNAL OF RHEUMATOLOGY
ISSN0315-162X
EISSN1499-2752
出版年2011
卷号38期号:2页码:322-324
英文摘要

Objective. Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22. We evaluated these new candidate genes in a large cohort of Korean patients with AS.


Methods. A group of 1164 patients with AS and 752 healthy controls were enrolled for our study. Eight single-nucleotide polymorphisms (SNP) were analyzed to define genetic association with AS by MassARRAY system.


Results. Significant positive associations of AS with endoplasmic reticulum aminopeptidase 1 SNP, rs27037 (p = 1.31 x 10(-4)), and rs27434 (p = 4.59 x 10(-6)), were observed. The rs10865331 of gene desert at 2p15 also showed a significant association with AS (p = 4.63 x 10(-5)).


Conclusion. This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS. (First Release Nov 1 2010; J Rheumatol 2011; 38:322-4; doi:10.3899/jrheum.100652)


英文关键词ANKYLOSING SPONDYLITIS ERAP1 2p15 KOREA SINGLE-NUCLEOTIDE POLYMORPHISM
类型Article
语种英语
国家South Korea ; USA ; Canada
收录类别SCI-E
WOS记录号WOS:000287173000022
WOS关键词GENOME-WIDE ASSOCIATION ; POLYMORPHISMS ; PATHOGENESIS ; VARIANTS
WOS类目Rheumatology
WOS研究方向Rheumatology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/169410
作者单位1.Hanyang Univ Hosp Rheumat Dis, Dept Rheumatol, Seoul 133792, South Korea;
2.Korean Minjok Leadership Acad, Gangwan Do, South Korea;
3.Eulji Univ, Taejon, South Korea;
4.Cornell Univ, Ithaca, NY USA;
5.Univ Texas Hlth Sci Ctr Houston, Houston, TX USA;
6.Mem Univ Newfoundland, St John, NF, Canada;
7.Newfound Genom, St John, NF, Canada;
8.Univ Toronto, Toronto Western Hosp, Toronto, ON M5T 2S8, Canada
推荐引用方式
GB/T 7714
Bang, So-Young,Kim, Tae-Hwan,Lee, Bitnara,et al. Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients[J],2011,38(2):322-324.
APA Bang, So-Young.,Kim, Tae-Hwan.,Lee, Bitnara.,Kwon, Eunji.,Choi, Sang Hyun.,...&Inman, Robert D..(2011).Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients.JOURNAL OF RHEUMATOLOGY,38(2),322-324.
MLA Bang, So-Young,et al."Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients".JOURNAL OF RHEUMATOLOGY 38.2(2011):322-324.
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