Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.3899/jrheum.100652 |
Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients | |
Bang, So-Young1; Kim, Tae-Hwan1; Lee, Bitnara1; Kwon, Eunji1; Choi, Sang Hyun2; Lee, Ki Soo4; Shim, Seung Cheol3; Pope, Angela7; Rahman, Proton6; Reveille, John D.5; Inman, Robert D.8 | |
通讯作者 | Kim, Tae-Hwan |
来源期刊 | JOURNAL OF RHEUMATOLOGY
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ISSN | 0315-162X |
EISSN | 1499-2752 |
出版年 | 2011 |
卷号 | 38期号:2页码:322-324 |
英文摘要 | Objective. Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22. We evaluated these new candidate genes in a large cohort of Korean patients with AS. Methods. A group of 1164 patients with AS and 752 healthy controls were enrolled for our study. Eight single-nucleotide polymorphisms (SNP) were analyzed to define genetic association with AS by MassARRAY system. Results. Significant positive associations of AS with endoplasmic reticulum aminopeptidase 1 SNP, rs27037 (p = 1.31 x 10(-4)), and rs27434 (p = 4.59 x 10(-6)), were observed. The rs10865331 of gene desert at 2p15 also showed a significant association with AS (p = 4.63 x 10(-5)). Conclusion. This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS. (First Release Nov 1 2010; J Rheumatol 2011; 38:322-4; doi:10.3899/jrheum.100652) |
英文关键词 | ANKYLOSING SPONDYLITIS ERAP1 2p15 KOREA SINGLE-NUCLEOTIDE POLYMORPHISM |
类型 | Article |
语种 | 英语 |
国家 | South Korea ; USA ; Canada |
收录类别 | SCI-E |
WOS记录号 | WOS:000287173000022 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; POLYMORPHISMS ; PATHOGENESIS ; VARIANTS |
WOS类目 | Rheumatology |
WOS研究方向 | Rheumatology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/169410 |
作者单位 | 1.Hanyang Univ Hosp Rheumat Dis, Dept Rheumatol, Seoul 133792, South Korea; 2.Korean Minjok Leadership Acad, Gangwan Do, South Korea; 3.Eulji Univ, Taejon, South Korea; 4.Cornell Univ, Ithaca, NY USA; 5.Univ Texas Hlth Sci Ctr Houston, Houston, TX USA; 6.Mem Univ Newfoundland, St John, NF, Canada; 7.Newfound Genom, St John, NF, Canada; 8.Univ Toronto, Toronto Western Hosp, Toronto, ON M5T 2S8, Canada |
推荐引用方式 GB/T 7714 | Bang, So-Young,Kim, Tae-Hwan,Lee, Bitnara,et al. Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients[J],2011,38(2):322-324. |
APA | Bang, So-Young.,Kim, Tae-Hwan.,Lee, Bitnara.,Kwon, Eunji.,Choi, Sang Hyun.,...&Inman, Robert D..(2011).Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients.JOURNAL OF RHEUMATOLOGY,38(2),322-324. |
MLA | Bang, So-Young,et al."Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients".JOURNAL OF RHEUMATOLOGY 38.2(2011):322-324. |
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