Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1021/np200320u |
Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp. | |
Rateb, Mostafa E.1,2; Houssen, Wael E.1,3; Arnold, Markus3; Abdelrahman, Mostafa H.1; Deng, Hai1; Harrison, William T. A.1; Okoro, Chinyere K.4; Asenjo, Juan A.5; Andrews, Barbara A.5; Ferguson, Gail3; Bull, Alan T.6; Goodfellow, Michael4; Ebel, Rainer1; Jaspars, Marcel1 | |
通讯作者 | Jaspars, Marcel |
来源期刊 | JOURNAL OF NATURAL PRODUCTS
![]() |
ISSN | 0163-3864 |
出版年 | 2011 |
卷号 | 74期号:6页码:1491-1499 |
英文摘要 | Streptomyces sp. strain C34, isolated from soil collected in the Chilean hyper-arid Atacama Desert, was cultured on different media, resulting in the isolation and identification of four new ansamycin-type polyketides. The organism was selected for chemical investigation on the basis of a genome-mining PCR-based experiment targeting the gene encoding rifamycin-specific 3-amino5-hydroxybenzoic acid synthetase (AHBA). The isolated compounds were structurally characterized using NMR and MS techniques and named chaxamycins A D (1-4). Compounds 1-4 were tested for their antibacterial activity against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 and for their ability to inhibit the intrinsic ATPase activity of the heat shock protein 90 (Hsp90). Chaxamycin D (4), which showed a selective antibacterial activity against S. aureus ATCC 25923, was tested further against a panel of MRSA clinical isolates. In a virtual screening experiment, chaxamycins A D (1-4) have also been docked into the ATP-binding pocket in the N-terminal domain of the Hsp90, and the observed interactions are discussed. |
类型 | Article |
语种 | 英语 |
国家 | Scotland ; Egypt ; England ; Chile |
收录类别 | SCI-E |
WOS记录号 | WOS:000291920600019 |
WOS关键词 | 3-AMINO-5-HYDROXYBENZOIC ACID ; GENOME SEQUENCE ; HSP90 ; INHIBITORS ; DISCOVERY ; IDENTIFICATION ; BIOSYNTHESIS ; ANTIBIOTICS ; METABOLITES ; AFFINITY |
WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/169362 |
作者单位 | 1.Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland; 2.Beni Suef Univ, Dept Pharmacognosy, Fac Pharm, Bani Suwayf 32514, Egypt; 3.Univ Aberdeen, Inst Med Sci, Sch Med & Dent, Aberdeen AB25 2ZD, Scotland; 4.Univ Newcastle, Sch Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England; 5.Univ Chile, Ctr Syst Biol, Santiago, Chile; 6.Univ Kent, Sch Biosci, Canterbury CT2 7NJ, Kent, England |
推荐引用方式 GB/T 7714 | Rateb, Mostafa E.,Houssen, Wael E.,Arnold, Markus,et al. Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp.[J],2011,74(6):1491-1499. |
APA | Rateb, Mostafa E..,Houssen, Wael E..,Arnold, Markus.,Abdelrahman, Mostafa H..,Deng, Hai.,...&Jaspars, Marcel.(2011).Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp..JOURNAL OF NATURAL PRODUCTS,74(6),1491-1499. |
MLA | Rateb, Mostafa E.,et al."Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp.".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1491-1499. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。