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DOI10.1016/j.chroma.2011.01.060
Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionisation tandem mass spectrometry
Baker, David R.2; Kasprzyk-Hordern, Barbara1,2
通讯作者Kasprzyk-Hordern, Barbara
来源期刊JOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
EISSN1873-3778
出版年2011
卷号1218期号:12页码:1620-1631
英文摘要

A new-multi residue method was developed for the environmental monitoring of 65 stimulants, opiod and morphine derivatives, benzodiazepines, antidepressants, dissociative anaesthetics, drug precursors, human urine indicators and their metabolites in wastewater and surface water. The proposed analytical methodology offers rapid analysis for a large number of compounds, with low limits of quantification and utilises only one solid-phase extraction-ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry (SPE-LC-MS/MS) method, thus overcoming the drawbacks of previously published procedures. The method employed solid phase extraction with the usage of Oasis MCX sorbent and subsequent ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry. The usage of a 1.7 mu m particle size column (1 mm x 150 mm) resulted in very low flow rates (0.04 mL min(-1)), and as a consequence gave good sensitivity, low mobile phase consumption and short retention times for all compounds (from 2.9 to 23.1 min). High SPE recoveries (>60%) were obtained for the majority of compounds. The mean correlation coefficients of the calibration curves were typically higher than 0.997 and showed good linearity in the range 0-1000 mu g L-1. The method limits of detection ranged from 0.1 ng L-1 for compounds including cocaine, benzoylecgonine, norbenzoylecgonine and 2-oxo-3-hydroxy-LSD to 100 ng L-1 for caffeine. Method quantification limits ranged from 0.5 to 154.2 ng L-1. Intra-and inter-day repeatabilities were on average less than 10%. The method accuracy range was within -33.1 to 30.1%. The new multi-residue method was used to analyse drugs of abuse in wastewater and river water in the UK environment. Of the targeted 65 compounds, 46 analytes were detected at levels above the method quantification limit (MQL) in wastewater treatment plant (WWTP) influent, 43 in WWTP effluent and 36 compounds in river water. (C) 2011 Elsevier B.V. All rights reserved.


英文关键词Illicit drugs Drugs of abuse Precursors UPLC Wastewater Surface water Environment LC-MS/MS Sewage Crack cocaine SPE Pharmaceuticals Multi-residue
类型Article
语种英语
国家England
收录类别SCI-E
WOS记录号WOS:000288725300009
WOS关键词ILLICIT DRUGS ; STIMULATORY DRUGS ; METABOLITES ; COCAINE ; PHARMACEUTICALS ; URINE ; REMOVAL ; BELGIUM ; SAMPLES ; MS/MS
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/169016
作者单位1.Univ Bath, Dept Chem, Fac Sci, Bath BA2 7AY, Avon, England;
2.Univ Huddersfield, Dept Chem & Biol Sci, Sch Appl Sci, Huddersfield HD1 3DH, W Yorkshire, England
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Baker, David R.,Kasprzyk-Hordern, Barbara. Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionisation tandem mass spectrometry[J],2011,1218(12):1620-1631.
APA Baker, David R.,&Kasprzyk-Hordern, Barbara.(2011).Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionisation tandem mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1218(12),1620-1631.
MLA Baker, David R.,et al."Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionisation tandem mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1218.12(2011):1620-1631.
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