Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.1038/ja.2011.96 |
| Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp C38 | |
| Nachtigall, Jonny2; Kulik, Andreas1; Helaly, Soleiman2; Bull, Alan T.3; Goodfellow, Michael4; Asenjo, Juan A.5; Maier, Armin6; Wiese, Jutta7; Imhoff, Johannes F.7; Suessmuth, Roderich D.2; Fiedler, Hans-Peter1 | |
| 通讯作者 | Fiedler, Hans-Peter |
| 来源期刊 | JOURNAL OF ANTIBIOTICS
 |
| ISSN | 0021-8820 |
| 出版年 | 2011 |
| 卷号 | 64期号:12页码:775-780 |
| 英文摘要 | Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells. The Journal of Antibiotics (2011) 64, 775-780; doi: 10.1038/ja.2011.96; published online 19 October 2011 |
| 英文关键词 | antitumor agents atacamycins hyper-arid soils 22-membered macrolactone antibiotics phosphodiesterase 4 inhibitors Streptomyces |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | Germany ; England ; Chile |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000298634600004 |
| WOS关键词 | DESERT ; MACROLIDES ; CHILE ; METABOLITES ; ARIDITY ; STRAIN ; SOILS |
| WOS类目 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/168799 |
| 作者单位 | 1.Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany; 2.Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany; 3.Univ Kent, Res Sch Biosci, Canterbury, Kent, England; 4.Newcastle Univ, Sch Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England; 5.Univ Chile, Dept Chem Engn & Biotechnol, Santiago, Chile; 6.Oncotest GmbH, Inst Expt Oncol, Freiburg, Germany; 7.Leibniz Inst Meereswissensch, Kieler Wirkstoff Zentrum, Kiel, Germany |
| 推荐引用方式 GB/T 7714 | Nachtigall, Jonny,Kulik, Andreas,Helaly, Soleiman,et al. Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp C38[J],2011,64(12):775-780. |
| APA | Nachtigall, Jonny.,Kulik, Andreas.,Helaly, Soleiman.,Bull, Alan T..,Goodfellow, Michael.,...&Fiedler, Hans-Peter.(2011).Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp C38.JOURNAL OF ANTIBIOTICS,64(12),775-780. |
| MLA | Nachtigall, Jonny,et al."Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp C38".JOURNAL OF ANTIBIOTICS 64.12(2011):775-780. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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