Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1093/ilar.52.1.41 |
Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research | |
Edrey, Yael H.; Hanes, Martha2; Pinto, Mario3,4; Mele, James; Buffenstein, Rochelle1 | |
通讯作者 | Buffenstein, Rochelle |
来源期刊 | ILAR JOURNAL
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ISSN | 1084-2020 |
EISSN | 1930-6180 |
出版年 | 2011 |
卷号 | 52期号:1页码:41-53 |
英文摘要 | Naked mole rats (NMRs; Heterocephalus glaber) are the longest-living rodents known, with a maximum lifespan of 30 years-5 times longer than expected on the basis of body size. These highly social mouse-sized rodents, naturally found in subterranean burrows in the arid and semiarid regions of the horn of Africa, are commonly used in behavioral, neurological, and ecophysiological research. Very old NMRs (>28 years), like humans, show signs of age-associated pathologies (e. g., muscle loss) as well as the accumulation of lipofuscin pigments, but no signs of tumorigenesis. Indeed, for at least 80% of their lives NMRs maintain normal activity, body composition, and reproductive and physiological functions with no obvious age-related increases in morbidity or mortality rate. Their long lifespan is attributed to sustained good health and pronounced cancer resistance. Clearly physiological and biochemical processes in this species have evolved to dramatically extend both their good health-and lifespan. We and others have tested various current theories using this species as an exceptionally long-lived animal model of successful abrogated aging. Surprisingly, NMRs have high levels of oxidative stress and relatively short telomeres, yet they are extremely resilient when subjected to cellular stressors and appear capable of sustaining both their genomic and protein integrity under hostile conditions. The challenge is to understand how these animals are able to do this. Elucidating these mechanisms will provide useful information for enhancing human life-and health-span, making the naked mole rat a true "supermodel" for aging research and resistance to chronic age-associated diseases. |
英文关键词 | age-associated pathology aging cancer resistance ecophysiology metabolism glucose regulation naked mole rat (Heterocephalus glaber) oxidative stress |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000291388900006 |
WOS关键词 | OXIDATIVE STRESS THEORY ; AGE-RELATED-CHANGES ; HETEROCEPHALUS-GLABER ; LIVING RODENT ; LIFE-SPAN ; DROSOPHILA-MELANOGASTER ; MEMBRANE-COMPOSITION ; GENOME SEQUENCE ; METABOLIC-RATE ; VISUAL-SYSTEM |
WOS类目 | Veterinary Sciences |
WOS研究方向 | Veterinary Sciences |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/168488 |
作者单位 | 1.UTHSCSA, Sam & Ann Barshop Inst Longev & Aging Studies, Dept Physiol, San Antonio, TX 78245 USA; 2.UTHSCSA, Dept Lab Anim Resources, San Antonio, TX 78245 USA; 3.CUNY, Dept Biol, New York, NY USA; 4.CUNY, Barshop Inst, New York, NY USA |
推荐引用方式 GB/T 7714 | Edrey, Yael H.,Hanes, Martha,Pinto, Mario,et al. Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research[J],2011,52(1):41-53. |
APA | Edrey, Yael H.,Hanes, Martha,Pinto, Mario,Mele, James,&Buffenstein, Rochelle.(2011).Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research.ILAR JOURNAL,52(1),41-53. |
MLA | Edrey, Yael H.,et al."Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research".ILAR JOURNAL 52.1(2011):41-53. |
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