Arid
DOI10.1093/ilar.52.1.41
Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research
Edrey, Yael H.; Hanes, Martha2; Pinto, Mario3,4; Mele, James; Buffenstein, Rochelle1
通讯作者Buffenstein, Rochelle
来源期刊ILAR JOURNAL
ISSN1084-2020
EISSN1930-6180
出版年2011
卷号52期号:1页码:41-53
英文摘要

Naked mole rats (NMRs; Heterocephalus glaber) are the longest-living rodents known, with a maximum lifespan of 30 years-5 times longer than expected on the basis of body size. These highly social mouse-sized rodents, naturally found in subterranean burrows in the arid and semiarid regions of the horn of Africa, are commonly used in behavioral, neurological, and ecophysiological research. Very old NMRs (>28 years), like humans, show signs of age-associated pathologies (e. g., muscle loss) as well as the accumulation of lipofuscin pigments, but no signs of tumorigenesis. Indeed, for at least 80% of their lives NMRs maintain normal activity, body composition, and reproductive and physiological functions with no obvious age-related increases in morbidity or mortality rate. Their long lifespan is attributed to sustained good health and pronounced cancer resistance. Clearly physiological and biochemical processes in this species have evolved to dramatically extend both their good health-and lifespan. We and others have tested various current theories using this species as an exceptionally long-lived animal model of successful abrogated aging. Surprisingly, NMRs have high levels of oxidative stress and relatively short telomeres, yet they are extremely resilient when subjected to cellular stressors and appear capable of sustaining both their genomic and protein integrity under hostile conditions. The challenge is to understand how these animals are able to do this. Elucidating these mechanisms will provide useful information for enhancing human life-and health-span, making the naked mole rat a true "supermodel" for aging research and resistance to chronic age-associated diseases.


英文关键词age-associated pathology aging cancer resistance ecophysiology metabolism glucose regulation naked mole rat (Heterocephalus glaber) oxidative stress
类型Article
语种英语
国家USA
收录类别SCI-E
WOS记录号WOS:000291388900006
WOS关键词OXIDATIVE STRESS THEORY ; AGE-RELATED-CHANGES ; HETEROCEPHALUS-GLABER ; LIVING RODENT ; LIFE-SPAN ; DROSOPHILA-MELANOGASTER ; MEMBRANE-COMPOSITION ; GENOME SEQUENCE ; METABOLIC-RATE ; VISUAL-SYSTEM
WOS类目Veterinary Sciences
WOS研究方向Veterinary Sciences
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/168488
作者单位1.UTHSCSA, Sam & Ann Barshop Inst Longev & Aging Studies, Dept Physiol, San Antonio, TX 78245 USA;
2.UTHSCSA, Dept Lab Anim Resources, San Antonio, TX 78245 USA;
3.CUNY, Dept Biol, New York, NY USA;
4.CUNY, Barshop Inst, New York, NY USA
推荐引用方式
GB/T 7714
Edrey, Yael H.,Hanes, Martha,Pinto, Mario,et al. Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research[J],2011,52(1):41-53.
APA Edrey, Yael H.,Hanes, Martha,Pinto, Mario,Mele, James,&Buffenstein, Rochelle.(2011).Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research.ILAR JOURNAL,52(1),41-53.
MLA Edrey, Yael H.,et al."Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research".ILAR JOURNAL 52.1(2011):41-53.
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