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Geologically complex crystalline aquifers underlie large parts of the semi-arid Limpopo Province where some of the greatest groundwater needs in South Africa occur. It is important to identify potentially high-yielding zones that can be targeted for water supply. The study covered four distinct geologic and morpho-structural domains within Limpopo Province, together covering about 23,500 km(2). Results from over 2,500 pumping test analyses indicate that bedrock type (e.g. pegmatite), lithological setting (e.g. aureole of granitoids), proximity and orientation of dykes and lineaments, topographic setting (e.g. slopes or valleys) and proximity of surface-water drainages may exert an influence on borehole productivity. No correlation between borehole productivity and weathering depth was found. Lineaments and dykes striking perpendicular to the current maximum horizontal stress seem to be more favourable targets, which is inconsistent with the predicted regime. Due to the complex geologic history, it is difficult to link open discontinuities to a distinct recent or past tectonic event. Regional stress-field data, as in this case, may not account for local, possibly highly significant, stress-field variations. The hydrogeologic importance of several factors related to groundwater occurrence, here presented, can be used as a working reference for future groundwater development programmes.