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Stable isotope paleoaltimetry has been widely used to estimate Cenozoic surface elevation of major orogens. The influence of global climate change on stable isotope paleoaltimetry is uncertain, with proposals that warming could cause either overestimates or underestimates of past surface elevations. In this study we increase atmospheric pCO(2) by two and four times in an isotope-tracking atmospheric general circulation model to investigate the effect of global warming on oxygen isotopic compositions of precipitation (delta O-18(p)) over the continents. As in other climate models, the response in the GENESIS version 3 model to global warming is an amplification of upper troposphere temperatures through enhanced infrared absorption and a reduction in the surface to upper-level temperature gradient. Due to the temperature dependence of isotopic fractionation, vapor delta O-18 (delta O-18(v)) follows suit, leading to a reduction in the surface to upper troposphere delta O-18(v) gradient. In regions of subsidence, including the major orogens and deserts, downward mixing of O-18-enriched vapor from the troposphere to the near surface further reduces the lapse rate of delta O-18(v). As a consequence of these effects, the isotopic composition of precipitation in high-elevation regions, including the Tibetan Plateau, Rocky Mountains, European Alps, and Andean Plateau, increases by 3%-6% relative to that at low elevations. Neglect of this climate effect on high-elevation delta O-18(p) has likely led to underestimates of the surface elevation of Cenozoic orogens.