Arid
DOI10.1016/j.chemosphere.2010.11.073
In vitro biological effects of airborne PM2.5 and PM10 from a semi-desert city on the Mexico-US border
Osornio-Vargas, Alvaro R.1,2; Serrano, Jesus3; Rojas-Bracho, Leonora4; Miranda, Javier5; Garcia-Cuellar, Claudia2; Antonio Reyna, Marco6; Flores, Geraldine2; Zuk, Miriam4; Quintero, Margarito6; Vazquez, Ines2; Sanchez-Perez, Yesennia2; Lopez, Tania4; Rosas, Irma7
通讯作者Osornio-Vargas, Alvaro R.
来源期刊CHEMOSPHERE
ISSN0045-6535
出版年2011
卷号83期号:4页码:618-626
英文摘要

Compelling evidence indicates that exposure to urban airborne particulate matter (PM) affects health. However, how PM components interact with PM-size to cause adverse health effects needs elucidation, especially when considering soil and anthropogenic sources. We studied PM from Mexicali. Mexico, where soil particles contribute importantly to air pollution, expecting to differentiate in vitro effects related to PM-size and composition. PM samples with mean aerodynamic diameters <= 2.5 mu m (PM2.5) and <= 10 mu m (PM10) were collected in Mexicali (October 2005-March 2006) from a semi-urban (expected larger participation of soil sources) and an urban (predominately combustion sources) site. Samples were pooled by site and size, analyzed for elemental composition (particle-induced X-ray emission) and tested in vitro for: induction of human erythrocytes membrane disruption (hemolysis) (colorimetrically); inhibition of cell proliferation (ICP) (crystal violet) and TNF alpha/IL-6 secretion (ELISA) using J774.A1 murine monocytic cells; and DNA degradation using Balb/c3T3 cell naked DNA (electrophoretically). Results of PM elemental composition principal component analysis were used in associating cellular effects. Sixteen elements identified in PM grouped in two principal components: Component(1) (C-1): Mg, Al, Si. P. Cl, K, Ca, Ti, V. Cr, Fe, and Component(2) (C-2): Cu, Zn. Hemolysis was predominately induced by semi-urban-PM10 (p < 0.05) and was associated with urban-PM10 C-1 (r = 0.62, p = 0.003). Major ICP resulted with semi-urban PM2.5 (p < 0.05). TNF alpha, was mainly induced by urban samples regardless of size (p < 0.05) and associated with urban-PM2.5 C-2 (r = 0.48, p = 0.02). Both PM10 samples induced highest DNA degradation (p < 0.05), regardless of location. We conclude that PM-size and PM-related soil or anthropogenic elements trigger specific biological-response patterns. (C) 2010 Elsevier Ltd. All rights reserved.


英文关键词PM10 PM2.5 Mexicali Cytotoxicity Principal components analysis Elemental composition
类型Article
语种英语
国家Canada ; Mexico
收录类别SCI-E
WOS记录号WOS:000289879500032
WOS关键词PARTICULATE AIR-POLLUTION ; DAILY MORTALITY ; COARSE PARTICLES ; CHEMICAL-COMPOSITION ; HOSPITAL ADMISSIONS ; SEASONAL-VARIATIONS ; CELL TOXICITY ; MATTER ; SIZE ; HEALTH
WOS类目Environmental Sciences
WOS研究方向Environmental Sciences & Ecology
来源机构Universidad Nacional Autónoma de México
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/167578
作者单位1.Univ Alberta, Dept Paediat, Fac Med & Dent, Edmonton, AB T6G 2V2, Canada;
2.Inst Nacl Cancerol, Mexico City 14080, DF, Mexico;
3.Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico;
4.SEMARNAT, Inst Nacl Ecol, Mexico City 04350, DF, Mexico;
5.Univ Nacl Autonoma Mexico, Inst Fis, Mexico City 04510, DF, Mexico;
6.Univ Autonoma Baja California, Inst Ingn, Mexicali 21280, Baja California, Mexico;
7.Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Mexico City 04510, DF, Mexico
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GB/T 7714
Osornio-Vargas, Alvaro R.,Serrano, Jesus,Rojas-Bracho, Leonora,et al. In vitro biological effects of airborne PM2.5 and PM10 from a semi-desert city on the Mexico-US border[J]. Universidad Nacional Autónoma de México,2011,83(4):618-626.
APA Osornio-Vargas, Alvaro R..,Serrano, Jesus.,Rojas-Bracho, Leonora.,Miranda, Javier.,Garcia-Cuellar, Claudia.,...&Rosas, Irma.(2011).In vitro biological effects of airborne PM2.5 and PM10 from a semi-desert city on the Mexico-US border.CHEMOSPHERE,83(4),618-626.
MLA Osornio-Vargas, Alvaro R.,et al."In vitro biological effects of airborne PM2.5 and PM10 from a semi-desert city on the Mexico-US border".CHEMOSPHERE 83.4(2011):618-626.
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