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DOI	10.1016/j.biotechadv.2011.05.002
	Manufactured RBC - Rivers of blood, or an oasis in the desert?
	Timmins, N. E.; Nielsen, L. K.
通讯作者	Timmins, N. E.
来源期刊	BIOTECHNOLOGY ADVANCES
ISSN	0734-9750
EISSN	1873-1899
出版年	2011
卷号	29 期号:6 页码:661-666
英文摘要	Red blood cell (RBC) transfusion is an essential practice in modern medicine, one that is entirely dependent on the availability of donor blood. Constraints in donor supply have led to proposals that transfusible RBC could be manufactured from stem cells. While it is possible to generate small amounts of RBC in vitro, very large numbers of cells are required to be of clinical significance. We explore the challenges facing large scale manufacture of RBC and technological developments required for such a scenario to be realised. (C) 2011 Elsevier Inc. All rights reserved.
英文关键词	Red blood cells Erythropoiesis Blood transfusion Cell therapy Bioreactors Cell culture
类型	Review
语种	英语
国家	Australia
收录类别	SCI-E
WOS记录号	WOS:000296821900010
WOS关键词	EX-VIVO EXPANSION ; HEMATOPOIETIC STEM-CELLS ; UMBILICAL-CORD BLOOD ; ANTIBODY-PRODUCTION ; IN-VITRO ; GENERATION ; NICHE ; PH ; PROGENITORS ; ENUCLEATION
WOS类目	Biotechnology & Applied Microbiology
WOS研究方向	Biotechnology & Applied Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/167429
作者单位	Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Timmins, N. E.,Nielsen, L. K.. Manufactured RBC - Rivers of blood, or an oasis in the desert?[J],2011,29(6):661-666.
APA	Timmins, N. E.,&Nielsen, L. K..(2011).Manufactured RBC - Rivers of blood, or an oasis in the desert?.BIOTECHNOLOGY ADVANCES,29(6),661-666.
MLA	Timmins, N. E.,et al."Manufactured RBC - Rivers of blood, or an oasis in the desert?".BIOTECHNOLOGY ADVANCES 29.6(2011):661-666.