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The climatic effects of concurrent land-cover changes in Amazonia and Northeast Brazil (NEB) were evaluated by simulations using the Center for Weather Forecasting and Climate Studies Atmospheric General Circulation Model (CPTEC-AGCM). Three experiments were performed: Amazon savannization, NEB desertification and both land-cover changes occurring concurrently. We found that land-cover change from adjacent areas do affect both Amazon and NEB regions and that the negative precipitation anomaly in NEB due to concurrent land-cover changes in Amazon and NEB is weaker than the linear addition of the anomalies considering the land-cover changes separately (synergistic behaviour). A simple mechanism was proposed to explain this behaviour. Copyright. 2011 Royal Meteorological Society