Arid
DOI10.2298/ABS1104015A
EFFECTS OF RETAMA RAETAM (FORSSK.) WEBB & BERTHEL. (FABACEAE) ON THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ANIMALS
Al-Tubuly, Rida A.1; Auzi, Abdurazag A.2; Al-Etri-Endi, Amna A.1; Nahar, Lutfun3; Sarker, Satyajit D.4
通讯作者Al-Tubuly, Rida A.
来源期刊ARCHIVES OF BIOLOGICAL SCIENCES
ISSN0354-4664
出版年2011
卷号63期号:4页码:1015-1021
英文摘要

Retama raetam (Forssk.) Webb & Berthel. (Fabaceae), commonly known as ’raetam’ or ’broom bush’, is a desert shrub that grows abundantly in North-African countries, Palestine and Syria. Traditionally, this plant has been used as an abortifacient, a purgative and a vermifuge. In the present study, the effect of the methanol (MeOH) extract of the aerial parts of R. raetam on the central nervous system (CNS) has been evaluated using a mice model. In the photoelectrical cell test, the extract of R. raetam (ERR) at a dose of 125 mg/kg body weight did not exhibit any effect on the spontaneous motor activity in mice. At a dose of 250 mg/kg body weight, ERR increased ambulatory movement, but had no effect on the non-ambulatory movement, while a dose of 375 mg/kg body weight decreased both ambulatory and non-ambulatory movements. The effect of ERR on the anxiety levels and behaviors of mice was investigated using the elevated plus-maze test. At doses of 125, 250 and 375 mg/kg body weight, ERR decreased anxiety levels without showing an effect on the total activity; it did not affect anxiety levels but increased the total activity; it increased anxiety levels and decreased the total activity, respectively. In the diazepam-induced sleep test, ERR increased the onset of sleep without affecting the duration of sleep at the dose of 250 mg/kg body weight. The dose of 375 mg/kg body weight decreased the onset of sleep while increasing the duration of sleep. ERR did not exhibit any effect on the diazepam-induced sleep in the presence of flumazenil or picrotoxin.


英文关键词Retama raetam Fabaceae central nervous system (CNS) diazepam North Africa
类型Article
语种英语
国家Libya ; England
收录类别SCI-E
WOS记录号WOS:000299244500013
WOS关键词AQUEOUS EXTRACT ; MICE ; RATS ; OIL ; ANTIOXIDANT ; RECEPTOR ; TUNISIA ; ANXIETY
WOS类目Biology
WOS研究方向Life Sciences & Biomedicine - Other Topics
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/167155
作者单位1.Al Fateh Univ, Fac Pharm, Dept Pharmacol & Clin Pharm, Tripoli, Libya;
2.Al Fateh Univ, Fac Pharm, Dept Pharmacognosy, Tripoli, Libya;
3.Wolverhampton Univ, Drug Discovery & Design Res Div, Dept Pharm, Sch Appl Sci, Wolverhampton WV1 1LY, W Midlands, England;
4.Wolverhampton Univ, Dept Pharm, Sch Appl Sci, Wolverhampton WV1 1SB, W Midlands, England
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Al-Tubuly, Rida A.,Auzi, Abdurazag A.,Al-Etri-Endi, Amna A.,et al. EFFECTS OF RETAMA RAETAM (FORSSK.) WEBB & BERTHEL. (FABACEAE) ON THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ANIMALS[J],2011,63(4):1015-1021.
APA Al-Tubuly, Rida A.,Auzi, Abdurazag A.,Al-Etri-Endi, Amna A.,Nahar, Lutfun,&Sarker, Satyajit D..(2011).EFFECTS OF RETAMA RAETAM (FORSSK.) WEBB & BERTHEL. (FABACEAE) ON THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ANIMALS.ARCHIVES OF BIOLOGICAL SCIENCES,63(4),1015-1021.
MLA Al-Tubuly, Rida A.,et al."EFFECTS OF RETAMA RAETAM (FORSSK.) WEBB & BERTHEL. (FABACEAE) ON THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ANIMALS".ARCHIVES OF BIOLOGICAL SCIENCES 63.4(2011):1015-1021.
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