Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.2298/ABS1104015A |
EFFECTS OF RETAMA RAETAM (FORSSK.) WEBB & BERTHEL. (FABACEAE) ON THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ANIMALS | |
Al-Tubuly, Rida A.1; Auzi, Abdurazag A.2; Al-Etri-Endi, Amna A.1; Nahar, Lutfun3; Sarker, Satyajit D.4 | |
通讯作者 | Al-Tubuly, Rida A. |
来源期刊 | ARCHIVES OF BIOLOGICAL SCIENCES
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ISSN | 0354-4664 |
出版年 | 2011 |
卷号 | 63期号:4页码:1015-1021 |
英文摘要 | Retama raetam (Forssk.) Webb & Berthel. (Fabaceae), commonly known as ’raetam’ or ’broom bush’, is a desert shrub that grows abundantly in North-African countries, Palestine and Syria. Traditionally, this plant has been used as an abortifacient, a purgative and a vermifuge. In the present study, the effect of the methanol (MeOH) extract of the aerial parts of R. raetam on the central nervous system (CNS) has been evaluated using a mice model. In the photoelectrical cell test, the extract of R. raetam (ERR) at a dose of 125 mg/kg body weight did not exhibit any effect on the spontaneous motor activity in mice. At a dose of 250 mg/kg body weight, ERR increased ambulatory movement, but had no effect on the non-ambulatory movement, while a dose of 375 mg/kg body weight decreased both ambulatory and non-ambulatory movements. The effect of ERR on the anxiety levels and behaviors of mice was investigated using the elevated plus-maze test. At doses of 125, 250 and 375 mg/kg body weight, ERR decreased anxiety levels without showing an effect on the total activity; it did not affect anxiety levels but increased the total activity; it increased anxiety levels and decreased the total activity, respectively. In the diazepam-induced sleep test, ERR increased the onset of sleep without affecting the duration of sleep at the dose of 250 mg/kg body weight. The dose of 375 mg/kg body weight decreased the onset of sleep while increasing the duration of sleep. ERR did not exhibit any effect on the diazepam-induced sleep in the presence of flumazenil or picrotoxin. |
英文关键词 | Retama raetam Fabaceae central nervous system (CNS) diazepam North Africa |
类型 | Article |
语种 | 英语 |
国家 | Libya ; England |
收录类别 | SCI-E |
WOS记录号 | WOS:000299244500013 |
WOS关键词 | AQUEOUS EXTRACT ; MICE ; RATS ; OIL ; ANTIOXIDANT ; RECEPTOR ; TUNISIA ; ANXIETY |
WOS类目 | Biology |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/167155 |
作者单位 | 1.Al Fateh Univ, Fac Pharm, Dept Pharmacol & Clin Pharm, Tripoli, Libya; 2.Al Fateh Univ, Fac Pharm, Dept Pharmacognosy, Tripoli, Libya; 3.Wolverhampton Univ, Drug Discovery & Design Res Div, Dept Pharm, Sch Appl Sci, Wolverhampton WV1 1LY, W Midlands, England; 4.Wolverhampton Univ, Dept Pharm, Sch Appl Sci, Wolverhampton WV1 1SB, W Midlands, England |
推荐引用方式 GB/T 7714 | Al-Tubuly, Rida A.,Auzi, Abdurazag A.,Al-Etri-Endi, Amna A.,et al. EFFECTS OF RETAMA RAETAM (FORSSK.) WEBB & BERTHEL. (FABACEAE) ON THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ANIMALS[J],2011,63(4):1015-1021. |
APA | Al-Tubuly, Rida A.,Auzi, Abdurazag A.,Al-Etri-Endi, Amna A.,Nahar, Lutfun,&Sarker, Satyajit D..(2011).EFFECTS OF RETAMA RAETAM (FORSSK.) WEBB & BERTHEL. (FABACEAE) ON THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ANIMALS.ARCHIVES OF BIOLOGICAL SCIENCES,63(4),1015-1021. |
MLA | Al-Tubuly, Rida A.,et al."EFFECTS OF RETAMA RAETAM (FORSSK.) WEBB & BERTHEL. (FABACEAE) ON THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ANIMALS".ARCHIVES OF BIOLOGICAL SCIENCES 63.4(2011):1015-1021. |
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