干旱区生态环境知识资源中心(Arid): 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC

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DOI	10.1073/pnas.0910668107
	8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
	Ahmadiyeh, Nasim 1,3; Pomerantz, Mark M.1; Grisanzio, Chiara 1; Herman, Paula 1; Jia, Li 4; Almendro, Vanessa 1; He, Housheng Hansen 1,2; Brown, Myles 1; Liu, X. Shirley 1,2; Davis, Matt 1; Caswell, Jennifer L.1; Beckwith, Christine A.1; Hills, Adam 1; MacConaill, Laura 1; Coetzee, Gerhard A.5; Regan, Meredith M.2; Freedman, Matthew L.1,6
通讯作者	Freedman, Matthew L.
来源期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
出版年	2010
卷号	107 期号:21 页码:9742-9746
英文摘要	The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC.
英文关键词	chromosome conformation capture epigenetic genetics
类型	Article
语种	英语
国家	USA
收录类别	SCI-E
WOS记录号	WOS:000278054700049
WOS关键词	GENOME-WIDE ASSOCIATION ; COLORECTAL-CANCER ; GENE-EXPRESSION ; ACTIVE CHROMATIN ; CHROMOSOME 8Q24 ; SUSCEPTIBILITY ; ENHANCERS ; VARIANT ; RS6983267 ; SCAN
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/166099
作者单位	1.Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA; 2.Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA; 3.Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA; 4.Washington Univ, Sch Med, Dept Internal Med, Ctr Pharmacogenom, St Louis, MO 63110 USA; 5.Univ So Calif, Norris Canc Ctr, Dept Urol, Los Angeles, CA 90033 USA; 6.Eli & Edythe L Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
推荐引用方式 GB/T 7714	Ahmadiyeh, Nasim,Pomerantz, Mark M.,Grisanzio, Chiara,et al. 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC[J],2010,107(21):9742-9746.
APA	Ahmadiyeh, Nasim.,Pomerantz, Mark M..,Grisanzio, Chiara.,Herman, Paula.,Jia, Li.,...&Freedman, Matthew L..(2010).8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(21),9742-9746.
MLA	Ahmadiyeh, Nasim,et al."8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.21(2010):9742-9746.