干旱区生态环境知识资源中心(Arid): Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

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DOI	10.1038/ng.513
	Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
	Reveille, John D.1; Sims, Anne-Marie 13; Danoy, Patrick 13; Evans, David M.2; Leo, Paul 13; Pointon, Jennifer J.3; Jin, Rui 1; Zhou, Xiaodong 1; Bradbury, Linda A.13; Appleton, Louise H.3; Davis, John C.4; Diekman, Laura 1; Doan, Tracey 13; Dowling, Alison 13; Duan, Ran 13; Duncan, Emma L.13; Farrar, Claire 3; Hadler, Johanna 13; Harvey, David 3; Karaderi, Tugce 3; Mogg, Rebecca 5,6; Pomeroy, Emma 5,6; Pryce, Karena 13; Taylor, Jacqueline 13; Savage, Laurie 7; Deloukas, Panos 8; Kumanduri, Vasudev 8; Peltonen, Leena 8; Ring, Sue M.2; Whittaker, Pamela 8; Glazov, Evgeny 13; Thomas, Gethin P.13; Maksymowych, Walter P.9; Inman, Robert D.10; Ward, Michael M.11; Stone, Millicent A.5,6,10; Weisman, Michael H.12; Wordsworth, B. Paul 3; Brown, Matthew A.3,13
通讯作者	Brown, Matthew A.
来源期刊	NATURE GENETICS
ISSN	1061-4036
EISSN	1546-1718
出版年	2010
卷号	42 期号:2 页码:123-U47
英文摘要	To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P < 10(-800)), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 x 10(-19)) and 21q22 (rs2242944; P = 8.3 x 10(-20)), as well as in the genes ANTXR2 (rs4333130; P = 9.3 x 10(-8)) and IL1R2 (rs2310173; P = 4.8 x 10(-7)). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 x 10(-14)) and ERAP1 (rs27434; P = 5.3 x 10(-12)). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility.
类型	Article
语种	英语
国家	USA ; England ; Canada ; Australia
收录类别	SCI-E
WOS记录号	WOS:000274084400007
WOS关键词	INFLAMMATORY-BOWEL-DISEASE ; GENETIC-SUSCEPTIBILITY ; VARIANTS ; POPULATION ; PHENOTYPES ; RISK ; TNF
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
来源机构	University of Oxford
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/165741
作者单位	1.Univ Texas Hlth Sci Ctr Houston, Houston, TX USA; 2.Univ Bristol, Dept Social Med, MRC, Ctr Causal Anal Translat Epidemiol, Bristol, Avon, England; 3.Univ Oxford, Botnar Res Ctr, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England; 4.Univ Calif San Francisco, San Francisco, CA 94143 USA; 5.Royal Natl Hosp Rheumat Dis, Natl Hlth Serv Fdn Trust, Bath BA1 1RL, Avon, England; 6.Univ Bath, Bath BA2 7AY, Avon, England; 7.Spondylitis Assoc Amer, Sherman Oaks, CA USA; 8.Wellcome Trust Sanger Inst, Cambridge, England; 9.Univ Alberta, Dept Med, Edmonton, AB, Canada; 10.Univ Toronto, Toronto, ON, Canada; 11.NIAMSD, NIH, Bethesda, MD 20892 USA; 12.Cedars Sinai Med Ctr, Dept Med Rheumatol, Los Angeles, CA 90048 USA; 13.Univ Queensland, Princess Alexandra Hosp, Diamantina Inst Canc Immunol & Metab Med, Brisbane, Qld, Australia
推荐引用方式 GB/T 7714	Reveille, John D.,Sims, Anne-Marie,Danoy, Patrick,et al. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci[J]. University of Oxford,2010,42(2):123-U47.
APA	Reveille, John D..,Sims, Anne-Marie.,Danoy, Patrick.,Evans, David M..,Leo, Paul.,...&Brown, Matthew A..(2010).Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.NATURE GENETICS,42(2),123-U47.
MLA	Reveille, John D.,et al."Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci".NATURE GENETICS 42.2(2010):123-U47.