Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.jtbi.2010.08.022 |
Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length | |
Mackiewicz, Dorota; Zawierta, Marta; Waga, Wojciech; Cebrat, Stanislaw | |
通讯作者 | Mackiewicz, Dorota |
来源期刊 | JOURNAL OF THEORETICAL BIOLOGY |
ISSN | 0022-5193 |
出版年 | 2010 |
卷号 | 267期号:2页码:186-192 |
英文摘要 | In the human genomes, recombination frequency between homologous chromosomes during meiosis is highly correlated with their physical length while it differs significantly when their coding density is considered. Furthermore, it has been observed that the recombination events are distributed unevenly along the chromosomes. We have found that many of such recombination properties can be predicted by computer simulations of population evolution based on the Monte Carlo methods. For example, these simulations have shown that the probability of acceptance of the recombination events by selection is higher at the ends of chromosomes and lower in their middle parts. The regions of high coding density are more prone to enter the strategy of haplotype complementation and to form clusters of genes, which are "recombination deserts". The phenomenon of switching in-between the purifying selection and haplotype complementation has a phase transition character, and many relations between the effective population size, coding density, chromosome size and recombination frequency are those of the power law type. (C) 2010 Elsevier Ltd. All rights reserved. |
英文关键词 | Crossover Complementation Gene linkage Monte Carlo simulation |
类型 | Article |
语种 | 英语 |
国家 | Poland |
收录类别 | SCI-E |
WOS记录号 | WOS:000283334100006 |
WOS关键词 | BIT-STRING MODEL ; MEIOTIC RECOMBINATION ; PHASE-TRANSITION ; DNA-SEQUENCE ; HOT-SPOTS ; EVOLUTION ; POPULATIONS ; GENES ; SEX ; KIR |
WOS类目 | Biology ; Mathematical & Computational Biology |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/165502 |
作者单位 | Univ Wroclaw, Biotechnol Fac, Dept Genom, PL-51148 Wroclaw, Poland |
推荐引用方式 GB/T 7714 | Mackiewicz, Dorota,Zawierta, Marta,Waga, Wojciech,et al. Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length[J],2010,267(2):186-192. |
APA | Mackiewicz, Dorota,Zawierta, Marta,Waga, Wojciech,&Cebrat, Stanislaw.(2010).Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length.JOURNAL OF THEORETICAL BIOLOGY,267(2),186-192. |
MLA | Mackiewicz, Dorota,et al."Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length".JOURNAL OF THEORETICAL BIOLOGY 267.2(2010):186-192. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。