Arid
DOI10.1016/j.jtbi.2010.08.022
Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length
Mackiewicz, Dorota; Zawierta, Marta; Waga, Wojciech; Cebrat, Stanislaw
通讯作者Mackiewicz, Dorota
来源期刊JOURNAL OF THEORETICAL BIOLOGY
ISSN0022-5193
出版年2010
卷号267期号:2页码:186-192
英文摘要

In the human genomes, recombination frequency between homologous chromosomes during meiosis is highly correlated with their physical length while it differs significantly when their coding density is considered. Furthermore, it has been observed that the recombination events are distributed unevenly along the chromosomes. We have found that many of such recombination properties can be predicted by computer simulations of population evolution based on the Monte Carlo methods. For example, these simulations have shown that the probability of acceptance of the recombination events by selection is higher at the ends of chromosomes and lower in their middle parts. The regions of high coding density are more prone to enter the strategy of haplotype complementation and to form clusters of genes, which are "recombination deserts". The phenomenon of switching in-between the purifying selection and haplotype complementation has a phase transition character, and many relations between the effective population size, coding density, chromosome size and recombination frequency are those of the power law type. (C) 2010 Elsevier Ltd. All rights reserved.


英文关键词Crossover Complementation Gene linkage Monte Carlo simulation
类型Article
语种英语
国家Poland
收录类别SCI-E
WOS记录号WOS:000283334100006
WOS关键词BIT-STRING MODEL ; MEIOTIC RECOMBINATION ; PHASE-TRANSITION ; DNA-SEQUENCE ; HOT-SPOTS ; EVOLUTION ; POPULATIONS ; GENES ; SEX ; KIR
WOS类目Biology ; Mathematical & Computational Biology
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/165502
作者单位Univ Wroclaw, Biotechnol Fac, Dept Genom, PL-51148 Wroclaw, Poland
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GB/T 7714
Mackiewicz, Dorota,Zawierta, Marta,Waga, Wojciech,et al. Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length[J],2010,267(2):186-192.
APA Mackiewicz, Dorota,Zawierta, Marta,Waga, Wojciech,&Cebrat, Stanislaw.(2010).Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length.JOURNAL OF THEORETICAL BIOLOGY,267(2),186-192.
MLA Mackiewicz, Dorota,et al."Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length".JOURNAL OF THEORETICAL BIOLOGY 267.2(2010):186-192.
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