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An analytical method was developed using ultra-high-pressure liquid chromatography-triple quadrupole-tandem m ass spectrometry (UHPLC-TQ-MS/MS) to simultaneously analyze 14 sulfonamides (SA) in 6 min Despite the rapidity oft he assay the system was properly re-equilibrated in this time No carryover was observed even after high analyze concentrations The instrumental detection limit based on signal-to-noise i atio (S/N) > 3, was below 1 pg/mu L (5 pg on Column) for all SAs except sulfachloropyridazine Surface water, ground water, soil. and slurry manure contained in storage ponds in and around swine [Sus scrofa domestricus] rearing facilities were analyzed Sample cleanup for ground water and surface water included using solid phase extraction (SPE) using Oasis (R) hydrophilic-lipophilic balance (HLB) cartridges The soil and slurry manure required tandem strong anion exchange (SAX) and HLB solid phase extraction cartridges for sample cleanup With few exceptions, the recoveries ranged from 60 to 100% for all matrices The minimum detectable levels were below 20ng/L for water, 30ng/L Cot slurry manure, and 45 ng/kg for soil except for sulfachloropyridazine The coefficient of variation (CV) was within 20% for most of the compounds analyzed Using this method, sulfamethazine concentrations of 2250-5060 ng/L, sulfamethoxazole concentrations of 108-1 47 x 10(6) ng/L, and sulfathrazole concentrations of 785-1700 ng/L were found in the slurry manure sulfadimethoxine (2 0-32 ng/L). sulfamethazine (20-5.1 ng/L). and sulfamethoxazone (20 5-43 0 ng/L.) were found In surface water and ground water In topsoil (0-15 cm). sulfamethazine ranged 345-663 ng/kg dry weight in those locations that received slurry manure as a nutrient, no SAs were found in the soil depths between 46 and (61 cm The speed makes the method pi actical for medium to high throughput applications The sensitivity and positive analyse identification make the method suitable for the demanding requirements for real world applications Published by Elsevier B V