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Multi-sensor comparisons are sometimes used due to limited image availability and temporal coverage by a single sensor. However, multi-sensor comparability is not well documented. Factors affecting direct comparability such as atmospheric conditions, landscape heterogeneity, landscape changes, and sensor characteristics are difficult to quantify. This study compared several vegetation indices (VIs) from multi-sensor data to determine if VIs are comparable across scales and sensors. Within-sensor comparisons demonstrate that VIs are consistent across spatial resolutions indicating a direct multi-scale comparability. However, among-sensor comparisons indicate that VIs calculated from different sensors are not comparable with one another regardless of spatial resolution. Sensor-specific characteristics appear to offer the best explanation for the observed results.