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DOI | 10.1007/s11682-010-9103-2 |
The neuroanatomic correlates of semantic memory deficits in patients with Gulf War illnesses: a pilot study | |
Calley, Clifford S.1; Kraut, Michael A.1,5; Spence, Jeffery S.4; Briggs, Richard W.2; Haley, Robert W.4; Hart, John, Jr.1,3 | |
通讯作者 | Hart, John, Jr. |
来源期刊 | BRAIN IMAGING AND BEHAVIOR |
ISSN | 1931-7557 |
出版年 | 2010 |
卷号 | 4期号:3-4页码:248-255 |
英文摘要 | We used functional magnetic resonance imaging (fMRI) to study semantic memory processing in 38 Gulf War veterans in 3 affected groups (Syndromes 1, 2, and 3) and normal-deployed controls. Subjects were given the Semantic Object Retrieval Test (SORT), which requires participants to decide whether two features combine and result in the retrieval of a specific object (e.g., "desert" and "humps" -> "camel"). Differences between groups were calculated using a repeated measures analysis of variance (ANOVA). Then, regions of interest were constructed and correlations assessed between the percent signal change (PSC) within these regions, followed by correlations between behavioral measures and PSC. We found affected groups performed less well on the SORT than the controls did, and behavioral differences were correlated to PSC within the caudate and thalamus. The combination of performance deficits and functional neuroimaging differences between affected Gulf War veterans and deployed normal controls begins to establish a neurobiological basis for their word-finding deficits. |
英文关键词 | Gulf War illness Semantic memory Word finding fMRI |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000282508600005 |
WOS关键词 | RETRIEVAL TEST SORT ; OBJECT-RECALL ; VETERANS ; ACTIVATION ; SYMPTOMS ; HEALTH |
WOS类目 | Neuroimaging |
WOS研究方向 | Neurosciences & Neurology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/163551 |
作者单位 | 1.Univ Texas Dallas, Ctr BrainHlth, Dallas, TX 75235 USA; 2.Univ Texas SW Med Ctr Dallas, Dept Radiol, Dallas, TX 75235 USA; 3.Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75235 USA; 4.Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75235 USA; 5.Johns Hopkins Sch Med, Dept Radiol, Baltimore, MD 21218 USA |
推荐引用方式 GB/T 7714 | Calley, Clifford S.,Kraut, Michael A.,Spence, Jeffery S.,et al. The neuroanatomic correlates of semantic memory deficits in patients with Gulf War illnesses: a pilot study[J],2010,4(3-4):248-255. |
APA | Calley, Clifford S.,Kraut, Michael A.,Spence, Jeffery S.,Briggs, Richard W.,Haley, Robert W.,&Hart, John, Jr..(2010).The neuroanatomic correlates of semantic memory deficits in patients with Gulf War illnesses: a pilot study.BRAIN IMAGING AND BEHAVIOR,4(3-4),248-255. |
MLA | Calley, Clifford S.,et al."The neuroanatomic correlates of semantic memory deficits in patients with Gulf War illnesses: a pilot study".BRAIN IMAGING AND BEHAVIOR 4.3-4(2010):248-255. |
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