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High Performance Liquid Chromatographic and Biological Studies of 2-[(4-Methyl-2-nitrophenyl)azo]-3-oxo-N-phenylbutanamide (Yellow Pigment)
Yenidogan, Semiha1; Oktav, Mehmet1; Ulgen, Mert2
通讯作者Yenidogan, Semiha
来源期刊ASIAN JOURNAL OF CHEMISTRY
ISSN0970-7077
出版年2010
卷号22期号:5页码:3705-3710
英文摘要

A simple reverse phase high performance liquid chromatographic (HPLC) method was developed for the quantitative determination of 4-methyl-2-nitroaniline (MNA) a potential reduction product of 2-[(4-methyl-2-nitrophenyl)azo]-3-oxo-N-phenylbutanamide (pigment yellow 1, PYI). Quantifications were carried out by Integrations of the peak areas using internal standardization method with N-(2.4-dichlorobenzoyl)aniline (DCBZA) as an internal standard The proposed dye (PY1) and its potential reduction product. 4-methyl-2-nitroaniline (MNA) arid the internal standard were separated by a reverse phase El PLC system The dye was then incubated with NADH to Investigate its possible reduction into the corresponding primary amine (MNA). However, no reduction was observed. The proposed compound was also incubated with rat microsomal preparations fortified with NADPH In both experiments, compounds in the incubates were extracted into dichloromethane (DCM) and finally evaporated under nitrogene. No metabolic reduction to MNA was observed as well. This indicates the in vitro stability of PYI and hence safety of the dye in tuns of potential toxicity from this reduction produet.


英文关键词Azo dyes In vitro metabolism Printing inks Am reduction 2-[(4-Methyl-2-nitrophenyl)azo]-3-oxo-N-phenylbutanamide HPLC
类型Article
语种英语
国家Turkey
收录类别SCI-E
WOS记录号WOS:000279844500052
WOS关键词AZO DYES ; REDUCTION ; PRODUCTS
WOS类目Chemistry, Multidisciplinary
WOS研究方向Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/163301
作者单位1.Marmara Univ Tech, Dept Printing, Fac Educ, TR-34722 Istanbul, Turkey;
2.Acibadem Univ, Sch Associated Hlth Sci, TR-34848 Istanbul, Turkey
推荐引用方式
GB/T 7714
Yenidogan, Semiha,Oktav, Mehmet,Ulgen, Mert. High Performance Liquid Chromatographic and Biological Studies of 2-[(4-Methyl-2-nitrophenyl)azo]-3-oxo-N-phenylbutanamide (Yellow Pigment)[J],2010,22(5):3705-3710.
APA Yenidogan, Semiha,Oktav, Mehmet,&Ulgen, Mert.(2010).High Performance Liquid Chromatographic and Biological Studies of 2-[(4-Methyl-2-nitrophenyl)azo]-3-oxo-N-phenylbutanamide (Yellow Pigment).ASIAN JOURNAL OF CHEMISTRY,22(5),3705-3710.
MLA Yenidogan, Semiha,et al."High Performance Liquid Chromatographic and Biological Studies of 2-[(4-Methyl-2-nitrophenyl)azo]-3-oxo-N-phenylbutanamide (Yellow Pigment)".ASIAN JOURNAL OF CHEMISTRY 22.5(2010):3705-3710.
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