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Non-uniformity of water distribution under irrigation system creates both deficit and surplus irrigation areas. Water salinity can be hazard on crop production; however, there is little information on the interaction of irrigation and salinity conditions on corn (Zea Mays) growth and production. This study evaluated the effect of salinity and irrigation levels on growth and yield of corn grown in the arid area of Egypt. A field experiment was conducted using corn grown in northern Egypt at Quesina, Menofia in 2009 summer season to evaluate amount of water applied, salinity hazard and their interactions. Three salinity levels and five irrigation treatments were arranged in a randomized split-plot design with salinity treatments as main plots and irrigation rates within salinity treatments. Salinity treatments were to apply fresh water (0.89 dS m(-1)). saline water (4.73 dS m(-1)), or mixing fresh plus saline water (2.81 dS m(-1)). Irrigation treatments were a ratio of crop evapotranspiration (ET) as: 0.6ET, 0.8ET, 1.0ET, 1.2ET, and 1.4ET. In well-watered conditions (1.0ET), seasonal water usable by corn was 453, 423, and 380 mm for 0.89EC, 2.81 EC and 4.73 EC over the 122-day growing season, respectively. Soil salt accumulation was significantly increased by either irrigation salinity increase or amount decrease. But, soil infiltration was significantly decreased by either salinity level or its interaction with irrigation amount. Leaf temperature, transpiration rate, and stomata resistance were significantly affected by both irrigation and salinity levels with interaction. Leaf area index, harvest index, and yield were the greatest when fresh and adequate irrigation was applied. Grain yield was significantly affected in a linear relationship (r(2) >= 0.95) by either irrigation or salinity conditions with no interaction. An optimal irrigation scheduling was statistically developed based on crop response for a given salinity level to extrapolate data from the small experiment (uniform condition) to big field (non-uniformity condition) under the experiment constraints. (C) 2010 Elsevier B.V. All rights reserved.