Arid
DOI10.1007/s00428-009-0753-7
Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation
Alinger, Beate1; Kiesslich, Tobias2; Datz, Christian3; Aberger, Fritz4; Strasser, Felix1; Berr, Frieder2; Dietze, Otto1; Kaserer, Klaus5; Hauser-Kronberger, Cornelia1
通讯作者Hauser-Kronberger, Cornelia
来源期刊VIRCHOWS ARCHIV
ISSN0945-6317
EISSN1432-2307
出版年2009
卷号454期号:4页码:369-379
英文摘要

The Hedgehog (Hh) pathway is a main regulation cascade in embryonic differentiation. It is also present in adult tissues and unusual expression has been associated with formation of benign and malignant lesions. We examined the presence of the Hedgehog pathway in normal and pathological human colon tissue. Components investigated include Sonic (Shh), Indian (Ihh), and Desert Hedgehog (Dhh), Gli1, Gli2, Gli3, and Patched (Ptch). Pathological tissue samples comprised 23 benign and 20 malignant lesions of human colon. The influence of the Hedgehog pathway on differentiation and proliferation has been investigated by analyzing the effect of the pathway inhibitor Cyclopamine on human colon cancer cell lines HT29 and CaCo2. In normal colon, we detected expression of Shh and Dhh within the lining epithelium and Patched, Gli1, and Gli2 along the whole crypts. Within all benign lesions, positive staining of Shh, Dhh, Gli1, Gli2, and Ptch was detected. Expression of Shh and Dhh was restricted to single cell aggregates. Malignant lesions also displayed focal staining pattern for Shh and Dhh but to a much lesser extent. We conclude that Hedgehog signaling is involved rather in constant differentiation and renewing of the colonic lining epithelium than in cancer formation, growth, or proliferation.


英文关键词Hedgehog pathway Colon cancer Differentiation Proliferation Stem cells
类型Article
语种英语
国家Austria
收录类别SCI-E
WOS记录号WOS:000264841700002
WOS关键词SONIC-HEDGEHOG ; COLORECTAL-CANCER ; DIGESTIVE-TRACT ; MORPHOGENESIS ; EPITHELIUM ; PATHWAY ; CELLS ; TRANSCRIPTION ; MAINTENANCE ; EXPRESSION
WOS类目Pathology
WOS研究方向Pathology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/162782
作者单位1.Paracelsus Med Univ Salzburg, Dept Pathol, Gen Hosp, A-5020 Salzburg, Austria;
2.Paracelsus Med Univ Salzburg, Dept Internal Med 1, A-5020 Salzburg, Austria;
3.Teaching Hosp Paracelsus Med Univ Salzburg, Dept Internal Med, Gen Hosp Oberndorf, A-5110 Oberndorf, Austria;
4.Salzburg Univ, Dept Mol Biol, A-5020 Salzburg, Austria;
5.Vienna Med Univ, Dept Pathol, A-1090 Vienna, Austria
推荐引用方式
GB/T 7714
Alinger, Beate,Kiesslich, Tobias,Datz, Christian,et al. Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation[J],2009,454(4):369-379.
APA Alinger, Beate.,Kiesslich, Tobias.,Datz, Christian.,Aberger, Fritz.,Strasser, Felix.,...&Hauser-Kronberger, Cornelia.(2009).Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation.VIRCHOWS ARCHIV,454(4),369-379.
MLA Alinger, Beate,et al."Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation".VIRCHOWS ARCHIV 454.4(2009):369-379.
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