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DOI | 10.1007/s00428-009-0753-7 |
Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation | |
Alinger, Beate1; Kiesslich, Tobias2; Datz, Christian3; Aberger, Fritz4; Strasser, Felix1; Berr, Frieder2; Dietze, Otto1; Kaserer, Klaus5; Hauser-Kronberger, Cornelia1 | |
通讯作者 | Hauser-Kronberger, Cornelia |
来源期刊 | VIRCHOWS ARCHIV
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ISSN | 0945-6317 |
EISSN | 1432-2307 |
出版年 | 2009 |
卷号 | 454期号:4页码:369-379 |
英文摘要 | The Hedgehog (Hh) pathway is a main regulation cascade in embryonic differentiation. It is also present in adult tissues and unusual expression has been associated with formation of benign and malignant lesions. We examined the presence of the Hedgehog pathway in normal and pathological human colon tissue. Components investigated include Sonic (Shh), Indian (Ihh), and Desert Hedgehog (Dhh), Gli1, Gli2, Gli3, and Patched (Ptch). Pathological tissue samples comprised 23 benign and 20 malignant lesions of human colon. The influence of the Hedgehog pathway on differentiation and proliferation has been investigated by analyzing the effect of the pathway inhibitor Cyclopamine on human colon cancer cell lines HT29 and CaCo2. In normal colon, we detected expression of Shh and Dhh within the lining epithelium and Patched, Gli1, and Gli2 along the whole crypts. Within all benign lesions, positive staining of Shh, Dhh, Gli1, Gli2, and Ptch was detected. Expression of Shh and Dhh was restricted to single cell aggregates. Malignant lesions also displayed focal staining pattern for Shh and Dhh but to a much lesser extent. We conclude that Hedgehog signaling is involved rather in constant differentiation and renewing of the colonic lining epithelium than in cancer formation, growth, or proliferation. |
英文关键词 | Hedgehog pathway Colon cancer Differentiation Proliferation Stem cells |
类型 | Article |
语种 | 英语 |
国家 | Austria |
收录类别 | SCI-E |
WOS记录号 | WOS:000264841700002 |
WOS关键词 | SONIC-HEDGEHOG ; COLORECTAL-CANCER ; DIGESTIVE-TRACT ; MORPHOGENESIS ; EPITHELIUM ; PATHWAY ; CELLS ; TRANSCRIPTION ; MAINTENANCE ; EXPRESSION |
WOS类目 | Pathology |
WOS研究方向 | Pathology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/162782 |
作者单位 | 1.Paracelsus Med Univ Salzburg, Dept Pathol, Gen Hosp, A-5020 Salzburg, Austria; 2.Paracelsus Med Univ Salzburg, Dept Internal Med 1, A-5020 Salzburg, Austria; 3.Teaching Hosp Paracelsus Med Univ Salzburg, Dept Internal Med, Gen Hosp Oberndorf, A-5110 Oberndorf, Austria; 4.Salzburg Univ, Dept Mol Biol, A-5020 Salzburg, Austria; 5.Vienna Med Univ, Dept Pathol, A-1090 Vienna, Austria |
推荐引用方式 GB/T 7714 | Alinger, Beate,Kiesslich, Tobias,Datz, Christian,et al. Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation[J],2009,454(4):369-379. |
APA | Alinger, Beate.,Kiesslich, Tobias.,Datz, Christian.,Aberger, Fritz.,Strasser, Felix.,...&Hauser-Kronberger, Cornelia.(2009).Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation.VIRCHOWS ARCHIV,454(4),369-379. |
MLA | Alinger, Beate,et al."Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation".VIRCHOWS ARCHIV 454.4(2009):369-379. |
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