Arid
DOI10.1016/j.peptides.2008.07.026
Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors
Breugelmans, Bert; Simonet, Gert; van Hoef, Vincent; Van Soest, Sofie; Broeck, Jozef Vanden
通讯作者Breugelmans, Bert
来源期刊PEPTIDES
ISSN0196-9781
EISSN1873-5169
出版年2009
卷号30期号:3页码:622-632
英文摘要

Members of the pacifastin family are serine peptidase inhibitors, found in arthropods and have many members within different insect orders. Based on their structural characteristics, inhibitors of this peptide family are divided into two groups (I and II). Members of both groups exhibit specificity towards different types of serine peptidases. In addition, group I inhibitors display species selectivity. The specificity and selectivity of these inhibitors depends on the nature of their P1 residue and on additional interaction sites at the inhibitor’s surface. Functional analysis studies have shown that crustacean pacifastin plays a key role in the immune response, whereas insect pacifastin-like peptides have multiple regulatory functions in processes involved in immunity, reproduction, phase transition, etc. (c) 2008 Elsevier Inc. All rights reserved.


英文关键词Pacifastin-related peptide Serine peptidase inhibitor Arthropod Insect Immune response Species selectivity
类型Review
语种英语
国家Belgium
收录类别SCI-E
WOS记录号WOS:000264791300025
WOS关键词LOCUST SCHISTOCERCA-GREGARIA ; DESERT LOCUST ; PROTEINASE-INHIBITORS ; PROTEASE INHIBITORS ; CDNA CLONING ; MIGRATORY LOCUST ; INSECT PEPTIDES ; ACTIVE-SITE ; PROPHENOLOXIDASE ; ENZYME
WOS类目Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/162173
作者单位Katholieke Univ Leuven, Inst Zool, Dept Anim Physiol & Neurobiol, B-3000 Louvain, Belgium
推荐引用方式
GB/T 7714
Breugelmans, Bert,Simonet, Gert,van Hoef, Vincent,et al. Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors[J],2009,30(3):622-632.
APA Breugelmans, Bert,Simonet, Gert,van Hoef, Vincent,Van Soest, Sofie,&Broeck, Jozef Vanden.(2009).Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors.PEPTIDES,30(3),622-632.
MLA Breugelmans, Bert,et al."Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors".PEPTIDES 30.3(2009):622-632.
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