Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.peptides.2008.07.026 |
Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors | |
Breugelmans, Bert; Simonet, Gert; van Hoef, Vincent; Van Soest, Sofie; Broeck, Jozef Vanden | |
通讯作者 | Breugelmans, Bert |
来源期刊 | PEPTIDES
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ISSN | 0196-9781 |
EISSN | 1873-5169 |
出版年 | 2009 |
卷号 | 30期号:3页码:622-632 |
英文摘要 | Members of the pacifastin family are serine peptidase inhibitors, found in arthropods and have many members within different insect orders. Based on their structural characteristics, inhibitors of this peptide family are divided into two groups (I and II). Members of both groups exhibit specificity towards different types of serine peptidases. In addition, group I inhibitors display species selectivity. The specificity and selectivity of these inhibitors depends on the nature of their P1 residue and on additional interaction sites at the inhibitor’s surface. Functional analysis studies have shown that crustacean pacifastin plays a key role in the immune response, whereas insect pacifastin-like peptides have multiple regulatory functions in processes involved in immunity, reproduction, phase transition, etc. (c) 2008 Elsevier Inc. All rights reserved. |
英文关键词 | Pacifastin-related peptide Serine peptidase inhibitor Arthropod Insect Immune response Species selectivity |
类型 | Review |
语种 | 英语 |
国家 | Belgium |
收录类别 | SCI-E |
WOS记录号 | WOS:000264791300025 |
WOS关键词 | LOCUST SCHISTOCERCA-GREGARIA ; DESERT LOCUST ; PROTEINASE-INHIBITORS ; PROTEASE INHIBITORS ; CDNA CLONING ; MIGRATORY LOCUST ; INSECT PEPTIDES ; ACTIVE-SITE ; PROPHENOLOXIDASE ; ENZYME |
WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy |
WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/162173 |
作者单位 | Katholieke Univ Leuven, Inst Zool, Dept Anim Physiol & Neurobiol, B-3000 Louvain, Belgium |
推荐引用方式 GB/T 7714 | Breugelmans, Bert,Simonet, Gert,van Hoef, Vincent,et al. Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors[J],2009,30(3):622-632. |
APA | Breugelmans, Bert,Simonet, Gert,van Hoef, Vincent,Van Soest, Sofie,&Broeck, Jozef Vanden.(2009).Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors.PEPTIDES,30(3),622-632. |
MLA | Breugelmans, Bert,et al."Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors".PEPTIDES 30.3(2009):622-632. |
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