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The problematic lizard family Changjiangosauridae, representatives of which inhabited Asia in the Early Paleogene, is discussed. Six new species of this group, including Acrodontopsis robustus gen. et sp. nov., Agamimus gracilis gen. et sp. nov., Graminisaurus interruptus gen. et sp. nov., Khaichinsaurus reshetovi gen. et sp. nov., Lavatisaurus elegans gen. et sp. nov., and Lentisaurus giganteus gen. et sp. nov., from the Middle Eocene of the Khaichin Uul 2 locality (southern Gobi, Mongolia) are described. It is shown that Changjiangosauridae are probably related to the Late Cretaceous Isodontosauridae and recent Uromastycidae; independent development of a number of dental features in different lineages of Acrodonta (Iguania) is corroborated.