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DOI10.1111/j.1471-4159.2009.06188.x
Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice
Chihara, Kazuyasu1; Saito, Atsushi1; Murakami, Tomohiko1; Hino, Shin-ichiro1; Aoki, Yuri1; Sekiya, Hiroshi1; Aikawa, Yuji1; Wanaka, Akio2; Imaizumi, Kazunori1
通讯作者Imaizumi, Kazunori
来源期刊JOURNAL OF NEUROCHEMISTRY
ISSN0022-3042
EISSN1471-4159
出版年2009
卷号110期号:3页码:956-965
英文摘要

The endoplasmic reticulum (ER) stress response is a defense system for dealing with the accumulation of unfolded proteins in the ER lumen. Old astrocyte specifically induced substance (OASIS) is known to be expressed in astrocytes and involved in the ER stress response; however the function of OASIS in the injured brain has remained unclear. In this study, we examined the roles of OASIS in neuronal degeneration in the hippocampi of mice intraperitoneally injected with kainic acid (KA). OASIS mRNA was strongly induced in response to KA injection, with a similar time course to the induction of ER molecular chaperone immunoglobulin heavy chain binding protein mRNA. In situ hybridization showed that KA injection causes induction of immunoglobulin heavy chain binding protein mRNA in glial fibrillary acidic protein-positive astrocytes as well as in pyramidal neurons, although up-regulation of OASIS mRNA was only detected in glial fibrillary acidic protein-positive astrocytes. Primary cultured astrocytes, but not the neurons of OASIS-/- mice, revealed reduced vulnerability to ER stress. Furthermore, pyramidal neurons in the hippocampi of OASIS-/- mice were more susceptible to the toxicity induced by KA than those of wild-type mice. Taken together, these data suggest that OASIS expressed in astrocytes plays important roles in protection against the neuronal damage induced by KA.


英文关键词astrocyte chaperone endoplasmic reticulum stress kainic acid neuronal cell death
类型Article
语种英语
国家Japan
收录类别SCI-E
WOS记录号WOS:000267968700018
WOS关键词ENDOPLASMIC-RETICULUM STRESS ; TRANSCRIPTION FACTOR OASIS ; UNFOLDED-PROTEIN RESPONSE ; CREB/ATF-FAMILY ; RAT-BRAIN ; INJURY ; ASTROCYTES ; EXPRESSION ; DEATH ; POLYPEPTIDE
WOS类目Biochemistry & Molecular Biology ; Neurosciences
WOS研究方向Biochemistry & Molecular Biology ; Neurosciences & Neurology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/161708
作者单位1.Miyazaki Univ, Fac Med, Div Mol & Cellular Biol, Dept Anat, Miyazaki 8891692, Japan;
2.Nara Med Univ, Dept Anat & Neurosci, Nara, Japan
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Chihara, Kazuyasu,Saito, Atsushi,Murakami, Tomohiko,et al. Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice[J],2009,110(3):956-965.
APA Chihara, Kazuyasu.,Saito, Atsushi.,Murakami, Tomohiko.,Hino, Shin-ichiro.,Aoki, Yuri.,...&Imaizumi, Kazunori.(2009).Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice.JOURNAL OF NEUROCHEMISTRY,110(3),956-965.
MLA Chihara, Kazuyasu,et al."Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice".JOURNAL OF NEUROCHEMISTRY 110.3(2009):956-965.
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