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DOI | 10.1111/j.1471-4159.2009.06188.x |
Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice | |
Chihara, Kazuyasu1; Saito, Atsushi1; Murakami, Tomohiko1; Hino, Shin-ichiro1; Aoki, Yuri1; Sekiya, Hiroshi1; Aikawa, Yuji1; Wanaka, Akio2; Imaizumi, Kazunori1 | |
通讯作者 | Imaizumi, Kazunori |
来源期刊 | JOURNAL OF NEUROCHEMISTRY
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ISSN | 0022-3042 |
EISSN | 1471-4159 |
出版年 | 2009 |
卷号 | 110期号:3页码:956-965 |
英文摘要 | The endoplasmic reticulum (ER) stress response is a defense system for dealing with the accumulation of unfolded proteins in the ER lumen. Old astrocyte specifically induced substance (OASIS) is known to be expressed in astrocytes and involved in the ER stress response; however the function of OASIS in the injured brain has remained unclear. In this study, we examined the roles of OASIS in neuronal degeneration in the hippocampi of mice intraperitoneally injected with kainic acid (KA). OASIS mRNA was strongly induced in response to KA injection, with a similar time course to the induction of ER molecular chaperone immunoglobulin heavy chain binding protein mRNA. In situ hybridization showed that KA injection causes induction of immunoglobulin heavy chain binding protein mRNA in glial fibrillary acidic protein-positive astrocytes as well as in pyramidal neurons, although up-regulation of OASIS mRNA was only detected in glial fibrillary acidic protein-positive astrocytes. Primary cultured astrocytes, but not the neurons of OASIS-/- mice, revealed reduced vulnerability to ER stress. Furthermore, pyramidal neurons in the hippocampi of OASIS-/- mice were more susceptible to the toxicity induced by KA than those of wild-type mice. Taken together, these data suggest that OASIS expressed in astrocytes plays important roles in protection against the neuronal damage induced by KA. |
英文关键词 | astrocyte chaperone endoplasmic reticulum stress kainic acid neuronal cell death |
类型 | Article |
语种 | 英语 |
国家 | Japan |
收录类别 | SCI-E |
WOS记录号 | WOS:000267968700018 |
WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; TRANSCRIPTION FACTOR OASIS ; UNFOLDED-PROTEIN RESPONSE ; CREB/ATF-FAMILY ; RAT-BRAIN ; INJURY ; ASTROCYTES ; EXPRESSION ; DEATH ; POLYPEPTIDE |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/161708 |
作者单位 | 1.Miyazaki Univ, Fac Med, Div Mol & Cellular Biol, Dept Anat, Miyazaki 8891692, Japan; 2.Nara Med Univ, Dept Anat & Neurosci, Nara, Japan |
推荐引用方式 GB/T 7714 | Chihara, Kazuyasu,Saito, Atsushi,Murakami, Tomohiko,et al. Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice[J],2009,110(3):956-965. |
APA | Chihara, Kazuyasu.,Saito, Atsushi.,Murakami, Tomohiko.,Hino, Shin-ichiro.,Aoki, Yuri.,...&Imaizumi, Kazunori.(2009).Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice.JOURNAL OF NEUROCHEMISTRY,110(3),956-965. |
MLA | Chihara, Kazuyasu,et al."Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice".JOURNAL OF NEUROCHEMISTRY 110.3(2009):956-965. |
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