Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.chroma.2009.01.073 |
Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry | |
Ibanez, Maria; Guerrero, Carlos; Sancho, Juan V.; Hernandez, Felix | |
通讯作者 | Hernandez, Felix |
来源期刊 | JOURNAL OF CHROMATOGRAPHY A
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ISSN | 0021-9673 |
EISSN | 1873-3778 |
出版年 | 2009 |
卷号 | 1216期号:12页码:2529-2539 |
英文摘要 | The potential of ultra-high-pressure liquid chromatography (UHPLC) coupled to hybrid quadrupole time-of-flight mass spectrometry (QTOF-MS) for the screening and confirmation of antibiotics in water samples is illustrated in this paper. UHPLC presents several advantages over conventional liquid chromatography as it generates narrow peaks (increasing peak height and improving sensitivity) and reduces chromatographic runs. Regarding QTOF-MS. its increased mass resolution, high sensitivity in full-spectrum acquisition mode and mass accuracy, in both MS and MS/MS modes. make this technique ideal for the detection and reliable confirmation of organic contaminants in environmental samples. After a solid-phase extraction using Oasis HLB cartridges, UHPLC-QTOF-MS has been applied in this work to several types of water samples (Surface water and influent and effluent wastewaters). Several antibiotics were found in the samples, such as ofloxacin, ciprofloxacin, clarythromycin or erythromycin, among others. Moreover, the full spectrum data provided by TOF-MS acquisition has enabled searching for many other pharmaceuticals that could be present in the samples in a "post-target" way. This approach has allowed the detection and confirmation of paracetamol, omeprazole and codeine, among others. UPLC-QTOF-MS has been shown as an attractive and efficient hyphenated technique for the rapid detection and confirmation of pharmaceuticals in water with very little sample handling. (c) 2009 Elsevier B.V. All rights reserved. |
英文关键词 | Hybrid quadrupole time-of-flight mass spectrometry Ultra-high-pressure liquid chromatography Antibiotics Water Screening Confirmation Pharmaceuticals |
类型 | Article |
语种 | 英语 |
国家 | Spain |
收录类别 | SCI-E |
WOS记录号 | WOS:000264217800041 |
WOS关键词 | SOLID-PHASE EXTRACTION ; ENVIRONMENTAL-SAMPLES ; TRIPLE-QUADRUPOLE ; CONFIRMATION ; RESIDUES ; PHARMACEUTICALS ; QUANTIFICATION ; IDENTIFICATION ; EFFLUENT ; TETRACYCLINE |
WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/161407 |
作者单位 | Univ Jaume 1, Res Inst Pesticides & Water, E-12071 Castellon de La Plana, Spain |
推荐引用方式 GB/T 7714 | Ibanez, Maria,Guerrero, Carlos,Sancho, Juan V.,et al. Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry[J],2009,1216(12):2529-2539. |
APA | Ibanez, Maria,Guerrero, Carlos,Sancho, Juan V.,&Hernandez, Felix.(2009).Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1216(12),2529-2539. |
MLA | Ibanez, Maria,et al."Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1216.12(2009):2529-2539. |
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