Arid
DOI10.1016/j.chroma.2009.01.073
Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry
Ibanez, Maria; Guerrero, Carlos; Sancho, Juan V.; Hernandez, Felix
通讯作者Hernandez, Felix
来源期刊JOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
EISSN1873-3778
出版年2009
卷号1216期号:12页码:2529-2539
英文摘要

The potential of ultra-high-pressure liquid chromatography (UHPLC) coupled to hybrid quadrupole time-of-flight mass spectrometry (QTOF-MS) for the screening and confirmation of antibiotics in water samples is illustrated in this paper. UHPLC presents several advantages over conventional liquid chromatography as it generates narrow peaks (increasing peak height and improving sensitivity) and reduces chromatographic runs. Regarding QTOF-MS. its increased mass resolution, high sensitivity in full-spectrum acquisition mode and mass accuracy, in both MS and MS/MS modes. make this technique ideal for the detection and reliable confirmation of organic contaminants in environmental samples. After a solid-phase extraction using Oasis HLB cartridges, UHPLC-QTOF-MS has been applied in this work to several types of water samples (Surface water and influent and effluent wastewaters). Several antibiotics were found in the samples, such as ofloxacin, ciprofloxacin, clarythromycin or erythromycin, among others. Moreover, the full spectrum data provided by TOF-MS acquisition has enabled searching for many other pharmaceuticals that could be present in the samples in a "post-target" way. This approach has allowed the detection and confirmation of paracetamol, omeprazole and codeine, among others. UPLC-QTOF-MS has been shown as an attractive and efficient hyphenated technique for the rapid detection and confirmation of pharmaceuticals in water with very little sample handling. (c) 2009 Elsevier B.V. All rights reserved.


英文关键词Hybrid quadrupole time-of-flight mass spectrometry Ultra-high-pressure liquid chromatography Antibiotics Water Screening Confirmation Pharmaceuticals
类型Article
语种英语
国家Spain
收录类别SCI-E
WOS记录号WOS:000264217800041
WOS关键词SOLID-PHASE EXTRACTION ; ENVIRONMENTAL-SAMPLES ; TRIPLE-QUADRUPOLE ; CONFIRMATION ; RESIDUES ; PHARMACEUTICALS ; QUANTIFICATION ; IDENTIFICATION ; EFFLUENT ; TETRACYCLINE
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/161407
作者单位Univ Jaume 1, Res Inst Pesticides & Water, E-12071 Castellon de La Plana, Spain
推荐引用方式
GB/T 7714
Ibanez, Maria,Guerrero, Carlos,Sancho, Juan V.,et al. Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry[J],2009,1216(12):2529-2539.
APA Ibanez, Maria,Guerrero, Carlos,Sancho, Juan V.,&Hernandez, Felix.(2009).Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1216(12),2529-2539.
MLA Ibanez, Maria,et al."Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1216.12(2009):2529-2539.
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