Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1101/gr.087551.108 |
Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives | |
Sharpton, Thomas J.1; Stajich, Jason E.1; Rounsley, Steven D.2; Gardner, Malcolm J.3; Wortman, Jennifer R.4; Jordar, Vinita S.5; Maiti, Rama5; Kodira, Chinnappa D.6; Neafsey, Daniel E.6; Zeng, Qiandong6; Hung, Chiung-Yu7; McMahan, Cody7; Muszewska, Anna8; Grynberg, Marcin8; Mandel, M. Alejandra2; Kellner, Ellen M.2; Barker, Bridget M.2; Galgiani, John N.9; Orbach, Marc J.2; Kirkland, Theo N.10; Cole, Garry T.7; Henn, Matthew R.6; Birren, Bruce W.6; Taylor, John W.1 | |
通讯作者 | Sharpton, Thomas J. |
来源期刊 | GENOME RESEARCH |
ISSN | 1088-9051 |
出版年 | 2009 |
卷号 | 19期号:10页码:1722-1731 |
英文摘要 | While most Ascomycetes tend to associate principally with plants, the dimorphic fungi Coccidioides immitis and Coccidioides posadasii are primary pathogens of immunocompetent mammals, including humans. Infection results from environmental exposure to Coccidiodies, which is believed to grow as a soil saprophyte in arid deserts. To investigate hypotheses about the life history and evolution of Coccidioides, the genomes of several Onygenales, including C. immitis and C. posadasii; a close, nonpathogenic relative, Uncinocarpus reesii; and a more diverged pathogenic fungus, Histoplasma capsulatum, were sequenced and compared with those of 13 more distantly related Ascomycetes. This analysis identified increases and decreases in gene family size associated with a host/substrate shift from plants to animals in the Onygenales. In addition, comparison among Onygenales genomes revealed evolutionary changes in Coccidioides that may underlie its infectious phenotype, the identification of which may facilitate improved treatment and prevention of coccidioidomycosis. Overall, the results suggest that Coccidioides species are not soil saprophytes, but that they have evolved to remain associated with their dead animal hosts in soil, and that Coccidioides metabolism genes, membrane-related proteins, and putatively antigenic compounds have evolved in response to interaction with an animal host. |
类型 | Article |
语种 | 英语 |
国家 | USA ; Poland |
收录类别 | SCI-E |
WOS记录号 | WOS:000270389700004 |
WOS关键词 | MULTIPLE SEQUENCE ALIGNMENT ; INDUCED POINT MUTATION ; ASPERGILLUS-FUMIGATUS ; PHYLOGENETIC ANALYSIS ; MAXIMUM-LIKELIHOOD ; NEUROSPORA-CRASSA ; IMMITIS ; VIRULENCE ; DISEASE ; IDENTIFICATION |
WOS类目 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
来源机构 | University of Arizona ; University of California, Berkeley |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/160710 |
作者单位 | 1.Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA; 2.Univ Arizona, Dept Plant Sci, Tucson, AZ 85721 USA; 3.Seattle Biomed Res Inst, Dept Global Hlth, Seattle, WA 98109 USA; 4.Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA; 5.J Craig Venter Inst, Rockville, MD 20850 USA; 6.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; 7.Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA; 8.Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland; 9.Univ Arizona, Valley Fever Ctr Excellence, Tucson, AZ 85721 USA; 10.Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA |
推荐引用方式 GB/T 7714 | Sharpton, Thomas J.,Stajich, Jason E.,Rounsley, Steven D.,et al. Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives[J]. University of Arizona, University of California, Berkeley,2009,19(10):1722-1731. |
APA | Sharpton, Thomas J..,Stajich, Jason E..,Rounsley, Steven D..,Gardner, Malcolm J..,Wortman, Jennifer R..,...&Taylor, John W..(2009).Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives.GENOME RESEARCH,19(10),1722-1731. |
MLA | Sharpton, Thomas J.,et al."Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives".GENOME RESEARCH 19.10(2009):1722-1731. |
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