Arid
DOI10.1016/j.forsciint.2009.04.019
Suicidal death after injection of a castor bean extract (Ricinus communis L.)
Coopman, Vera1; De Leeuw, Marc2,3; Cordonnier, Jan1; Jacobs, Werner3
通讯作者Cordonnier, Jan
来源期刊FORENSIC SCIENCE INTERNATIONAL
ISSN0379-0738
EISSN1872-6283
出版年2009
卷号189期号:1-3页码:E13-E20
英文摘要

The castor bean plant (Ricinus communis L.) or wonder tree is cultivated in many countries as an ornamental annual plant in gardens. The highest concentration of the lectin ricin is present in the seeds and pods. Ricin is considered as one of the most toxic natural poisons. Ricinine is a piperidine alkaloidal toxin present in castor bean and is described as a biomarker for the exposure to ricin. A case report is presented of a 49-year-old man who committed suicide by intravenous and subcutaneous injection of a castor bean extract. He was brought to the emergency department 24 h after injecting himself. On admission, the patient was conscious and he presented with a history of nausea, vomiting, diarrhoea, dyspnoea, vertigo and muscular pain. Despite symptomatic and supportive intensive care, the man died 9 h after admission due to multiorgan failure.


A body external examination was performed. Blood, urine, vitreous humour and the castor bean extract were submitted to the laboratory for toxicological analysis. The identification of ricinine in the extract was performed by solid phase extraction in combination with full-scan gas chromatography/mass spectrometry, high-performance liquid chromatography with photodiode array detection and liquid chromatography/mass spectrometry operated in the full-scan mode, respectively. An extraction procedure with Oasis HLB solid phase extraction cartridges was applied. Chromatography was achieved using a Symmetry (R) C18 column using a gradient mode with 0.15% formic acid and 0.15% formic acid in acetonitrile as mobile phase.


Exposure to the castor bean extract was confirmed by identification of the biomarker ricinine in blood, urine and vitreous humour using solid phase extraction and liquid chromatography tandem mass spectrometry with electro spray source in positive ionization mode. Multiple reaction monitoring was used for specific detection. To the authors’ knowledge, it is the first time that ricinine has been identified in vitreous humour in a case of castor bean poisoning. Based on the clinical symptoms and the results of the toxicological analysis, we concluded that death was caused by intoxication with plant toxins originated from R. communis L. (C) 2009 Elsevier Ireland Ltd. All rights reserved.


英文关键词Ricinus communis L. Ricinine Lethal intoxication Injection LC-MS/MS
类型Article
语种英语
国家Belgium
收录类别SCI-E
WOS记录号WOS:000207819600003
WOS类目Medicine, Legal
WOS研究方向Legal Medicine
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/160656
作者单位1.Chemiphar NV, Dept Analyt Toxicol, B-8200 Brugge, Belgium;
2.Algemeen Stedelijk Ziekenhuis, Emergency Dept, B-9300 Aalst, Belgium;
3.Univ Antwerp Hosp, Ctr Forens Med, B-2650 Edegem, Belgium
推荐引用方式
GB/T 7714
Coopman, Vera,De Leeuw, Marc,Cordonnier, Jan,et al. Suicidal death after injection of a castor bean extract (Ricinus communis L.)[J],2009,189(1-3):E13-E20.
APA Coopman, Vera,De Leeuw, Marc,Cordonnier, Jan,&Jacobs, Werner.(2009).Suicidal death after injection of a castor bean extract (Ricinus communis L.).FORENSIC SCIENCE INTERNATIONAL,189(1-3),E13-E20.
MLA Coopman, Vera,et al."Suicidal death after injection of a castor bean extract (Ricinus communis L.)".FORENSIC SCIENCE INTERNATIONAL 189.1-3(2009):E13-E20.
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