Arid
DOI10.1007/s00125-009-1373-0
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)
Rich, S. S.1; Goodarzi, M. O.2; Palmer, N. D.3; Langefeld, C. D.4; Ziegler, J.4; Haffner, S. M.5; Bryer-Ash, M.6; Norris, J. M.7; Taylor, K. D.2; Haritunians, T.2; Rotter, J. I.2; Chen, Y. -D. I.2; Wagenknecht, L. E.4; Bowden, D. W.3; Bergman, R. N.8
通讯作者Rich, S. S.
来源期刊DIABETOLOGIA
ISSN0012-186X
EISSN1432-0428
出版年2009
卷号52期号:7页码:1326-1333
英文摘要

This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American participants from the Insulin Resistance Atherosclerosis Family Study (IRAS FS).


A two-stage genome-wide association scan (GWAS) was performed in IRAS FS Hispanic-American samples. In the first stage, 317K single nucleotide polymorphisms (SNPs) were assessed in 229 Hispanic-American DNA samples from 34 families from San Antonio, TX, USA. SNPs with the most significant associations with AIRg were genotyped in the entire set of IRAS FS Hispanic-American samples (n = 1,190). In chromosomal regions with evidence of association, additional SNPs were genotyped to capture variation in genes.


No individual SNP achieved genome-wide levels of significance (p < 5 x 10(-7)); however, two regions (chromosomes 6p21 and 20p11) had multiple highly ranked SNPs that were associated with AIRg. Additional genotyping in these regions supported the initial evidence of variants contributing to variation in AIRg. One region resides in a gene desert between PXT1 and KCTD20 on 6p21, while the region on 20p11 has several viable candidate genes (ENTPD6, PYGB, GINS1 and RP4-691N24.1).


A GWAS in Hispanic-American samples identified several candidate genes and loci that may be associated with AIRg. These associations explain a small component of variation in AIRg. The genes identified are involved in phosphorylation and ion transport, and provide preliminary evidence that these processes are important in beta cell response.


英文关键词Beta cell response Genetic association Hispanic-American Insulin secretion
类型Article
语种英语
国家USA
收录类别SCI-E
WOS记录号WOS:000266496000015
WOS关键词MINIMAL MODEL ; SECRETORY DYSFUNCTION ; SUSCEPTIBILITY LOCI ; DIABETES-MELLITUS ; LINKAGE ANALYSIS ; FASTING INSULIN ; PROTEIN-KINASE ; RISK LOCI ; SENSITIVITY ; POPULATION
WOS类目Endocrinology & Metabolism
WOS研究方向Endocrinology & Metabolism
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/160312
作者单位1.Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA;
2.Burns & Allen Cedars Sinai Res Inst, Inst Med Genet, Los Angeles, CA USA;
3.Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Ctr Human Genom & Diabet Res, Winston Salem, NC 27103 USA;
4.Wake Forest Univ, Bowman Gray Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27103 USA;
5.Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA;
6.Univ Oklahoma, Dept Med, Oklahoma City, OK USA;
7.Univ Colorado, Dept Epidemiol, Colorado Sch Publ Hlth, Denver, CO 80202 USA;
8.Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA
推荐引用方式
GB/T 7714
Rich, S. S.,Goodarzi, M. O.,Palmer, N. D.,et al. A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)[J],2009,52(7):1326-1333.
APA Rich, S. S..,Goodarzi, M. O..,Palmer, N. D..,Langefeld, C. D..,Ziegler, J..,...&Bergman, R. N..(2009).A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS).DIABETOLOGIA,52(7),1326-1333.
MLA Rich, S. S.,et al."A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)".DIABETOLOGIA 52.7(2009):1326-1333.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Rich, S. S.]的文章
[Goodarzi, M. O.]的文章
[Palmer, N. D.]的文章
百度学术
百度学术中相似的文章
[Rich, S. S.]的文章
[Goodarzi, M. O.]的文章
[Palmer, N. D.]的文章
必应学术
必应学术中相似的文章
[Rich, S. S.]的文章
[Goodarzi, M. O.]的文章
[Palmer, N. D.]的文章
相关权益政策
暂无数据
收藏/分享

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。