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DOI | 10.1007/s00125-009-1373-0 |
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS) | |
Rich, S. S.1; Goodarzi, M. O.2; Palmer, N. D.3; Langefeld, C. D.4; Ziegler, J.4; Haffner, S. M.5; Bryer-Ash, M.6; Norris, J. M.7; Taylor, K. D.2; Haritunians, T.2; Rotter, J. I.2; Chen, Y. -D. I.2; Wagenknecht, L. E.4; Bowden, D. W.3; Bergman, R. N.8 | |
通讯作者 | Rich, S. S. |
来源期刊 | DIABETOLOGIA
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ISSN | 0012-186X |
EISSN | 1432-0428 |
出版年 | 2009 |
卷号 | 52期号:7页码:1326-1333 |
英文摘要 | This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American participants from the Insulin Resistance Atherosclerosis Family Study (IRAS FS). A two-stage genome-wide association scan (GWAS) was performed in IRAS FS Hispanic-American samples. In the first stage, 317K single nucleotide polymorphisms (SNPs) were assessed in 229 Hispanic-American DNA samples from 34 families from San Antonio, TX, USA. SNPs with the most significant associations with AIRg were genotyped in the entire set of IRAS FS Hispanic-American samples (n = 1,190). In chromosomal regions with evidence of association, additional SNPs were genotyped to capture variation in genes. No individual SNP achieved genome-wide levels of significance (p < 5 x 10(-7)); however, two regions (chromosomes 6p21 and 20p11) had multiple highly ranked SNPs that were associated with AIRg. Additional genotyping in these regions supported the initial evidence of variants contributing to variation in AIRg. One region resides in a gene desert between PXT1 and KCTD20 on 6p21, while the region on 20p11 has several viable candidate genes (ENTPD6, PYGB, GINS1 and RP4-691N24.1). A GWAS in Hispanic-American samples identified several candidate genes and loci that may be associated with AIRg. These associations explain a small component of variation in AIRg. The genes identified are involved in phosphorylation and ion transport, and provide preliminary evidence that these processes are important in beta cell response. |
英文关键词 | Beta cell response Genetic association Hispanic-American Insulin secretion |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000266496000015 |
WOS关键词 | MINIMAL MODEL ; SECRETORY DYSFUNCTION ; SUSCEPTIBILITY LOCI ; DIABETES-MELLITUS ; LINKAGE ANALYSIS ; FASTING INSULIN ; PROTEIN-KINASE ; RISK LOCI ; SENSITIVITY ; POPULATION |
WOS类目 | Endocrinology & Metabolism |
WOS研究方向 | Endocrinology & Metabolism |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/160312 |
作者单位 | 1.Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA; 2.Burns & Allen Cedars Sinai Res Inst, Inst Med Genet, Los Angeles, CA USA; 3.Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Ctr Human Genom & Diabet Res, Winston Salem, NC 27103 USA; 4.Wake Forest Univ, Bowman Gray Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27103 USA; 5.Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA; 6.Univ Oklahoma, Dept Med, Oklahoma City, OK USA; 7.Univ Colorado, Dept Epidemiol, Colorado Sch Publ Hlth, Denver, CO 80202 USA; 8.Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA |
推荐引用方式 GB/T 7714 | Rich, S. S.,Goodarzi, M. O.,Palmer, N. D.,et al. A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)[J],2009,52(7):1326-1333. |
APA | Rich, S. S..,Goodarzi, M. O..,Palmer, N. D..,Langefeld, C. D..,Ziegler, J..,...&Bergman, R. N..(2009).A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS).DIABETOLOGIA,52(7),1326-1333. |
MLA | Rich, S. S.,et al."A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)".DIABETOLOGIA 52.7(2009):1326-1333. |
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