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A sensitive and reliable method by liquid chromatography-tandem mass spectrometry was developed for the simultaneous determination of carbadox, mequindox, olaquindox and quinocetone in swine feed. The analytes were extracted from swine feed with acetonitrile/water (60:40, v/v), and then further purified by solid-phase extraction using Oasis HLB cartridges. The mean recovery values ranged from 83-108%, and intra-day and inter-day variation were < 10.8 and 9.6%, respectively. The limits of quantification for the four compounds were < 20 mu g kg(-1). This procedure is applicable for detecting the four quinoxaline-1,4-dioxides in swine feed.