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DOI | 10.1016/j.bbr.2008.12.015 |
Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John’s wort-induced prepulse inhibition deficit: A possible role of hyperforin | |
Tadros, Mariane G.1; Mohamed, Mohamed R.2; Youssef, Amal M.3; Sabry, Gilane M.2; Sabry, Nagwa A.4; Khalifa, Amani E.1 | |
通讯作者 | Tadros, Mariane G. |
来源期刊 | BEHAVIOURAL BRAIN RESEARCH
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ISSN | 0166-4328 |
EISSN | 1872-7549 |
出版年 | 2009 |
卷号 | 199期号:2页码:334-339 |
英文摘要 | Prepulse inhibition (PPI) of acoustic startle response is a valuable Paradigm for sensorimotor gating processes. Previous research showed that acute administration of St. John’s wort extract (500 mg/kg, p.o.) to rats caused significant disruption of PPI while elevating monoamines levels in some brain areas. The cause-effect relationship between extract-induced PPI disruption and augmented monoaminergic transmission was studied using different serotoninergic, adrenergic and dopaminergic antagonists. The effects of hypericin and hyperforin, as the main active constituents of the extract, on PPI response were also tested. PPI disruption was prevented after blocking the serotoninergic 5-HT1A and 5-HT2A, alpha-adrenergic and dopaminergic D1 receptors. Results also demonstrated a significant PPI deficit after acute treatment of rats with hyperforin, and not hypericin. In some conditions manifesting disrupted PPI response, apoptosis coexists. Electrophoresis of DNA isolated from brains of hyperforin-treated animals revealed absence of any abnormal DNA fragmentation patterns. It is concluded that serotoninergic 5-HT1A arid 5-HT2A, alpha-adrenergic and dopaminergic D1 receptors are involved in the disruptive effect of St. John’s Wort extract on PPI response in rats. We can also conclude that hyperforin, arid not hypericin, is one of the active ingredients responsible for St. John’s wort-induced PPI disruption with no relation to apoptotic processes. (C) 2008 Elsevier B.V. All rights reserved. |
类型 | Article |
语种 | 英语 |
国家 | Egypt |
收录类别 | SCI-E |
WOS记录号 | WOS:000264953700022 |
WOS关键词 | HYPERICUM-PERFORATUM EXTRACT ; ACOUSTIC STARTLE RESPONSE ; ANTIDEPRESSANT ACTIVITY ; LOCOMOTOR-ACTIVITY ; PASSIVE-AVOIDANCE ; BRAIN-STEM ; L. EXTRACT ; RATS ; MICE ; TRANSPORTER |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/159956 |
作者单位 | 1.Ain Shams Univ, Dept Pharmacol & Toxicol, Fac Pharm, Cairo, Egypt; 2.Ain Shams Univ, Dept Biochem, Fac Sci, Cairo, Egypt; 3.Suez Canal Univ, Fac Med, Dept Physiol, Ismailia, Egypt; 4.Ain Shams Univ, Dept Clin Pharm, Fac Pharm, Cairo, Egypt |
推荐引用方式 GB/T 7714 | Tadros, Mariane G.,Mohamed, Mohamed R.,Youssef, Amal M.,等. Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John’s wort-induced prepulse inhibition deficit: A possible role of hyperforin[J],2009,199(2):334-339. |
APA | Tadros, Mariane G.,Mohamed, Mohamed R.,Youssef, Amal M.,Sabry, Gilane M.,Sabry, Nagwa A.,&Khalifa, Amani E..(2009).Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John’s wort-induced prepulse inhibition deficit: A possible role of hyperforin.BEHAVIOURAL BRAIN RESEARCH,199(2),334-339. |
MLA | Tadros, Mariane G.,et al."Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John’s wort-induced prepulse inhibition deficit: A possible role of hyperforin".BEHAVIOURAL BRAIN RESEARCH 199.2(2009):334-339. |
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