Arid
DOI10.1016/j.bbr.2008.12.015
Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John’s wort-induced prepulse inhibition deficit: A possible role of hyperforin
Tadros, Mariane G.1; Mohamed, Mohamed R.2; Youssef, Amal M.3; Sabry, Gilane M.2; Sabry, Nagwa A.4; Khalifa, Amani E.1
通讯作者Tadros, Mariane G.
来源期刊BEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
EISSN1872-7549
出版年2009
卷号199期号:2页码:334-339
英文摘要

Prepulse inhibition (PPI) of acoustic startle response is a valuable Paradigm for sensorimotor gating processes. Previous research showed that acute administration of St. John’s wort extract (500 mg/kg, p.o.) to rats caused significant disruption of PPI while elevating monoamines levels in some brain areas. The cause-effect relationship between extract-induced PPI disruption and augmented monoaminergic transmission was studied using different serotoninergic, adrenergic and dopaminergic antagonists. The effects of hypericin and hyperforin, as the main active constituents of the extract, on PPI response were also tested. PPI disruption was prevented after blocking the serotoninergic 5-HT1A and 5-HT2A, alpha-adrenergic and dopaminergic D1 receptors. Results also demonstrated a significant PPI deficit after acute treatment of rats with hyperforin, and not hypericin. In some conditions manifesting disrupted PPI response, apoptosis coexists. Electrophoresis of DNA isolated from brains of hyperforin-treated animals revealed absence of any abnormal DNA fragmentation patterns. It is concluded that serotoninergic 5-HT1A arid 5-HT2A, alpha-adrenergic and dopaminergic D1 receptors are involved in the disruptive effect of St. John’s Wort extract on PPI response in rats. We can also conclude that hyperforin, arid not hypericin, is one of the active ingredients responsible for St. John’s wort-induced PPI disruption with no relation to apoptotic processes. (C) 2008 Elsevier B.V. All rights reserved.


类型Article
语种英语
国家Egypt
收录类别SCI-E
WOS记录号WOS:000264953700022
WOS关键词HYPERICUM-PERFORATUM EXTRACT ; ACOUSTIC STARTLE RESPONSE ; ANTIDEPRESSANT ACTIVITY ; LOCOMOTOR-ACTIVITY ; PASSIVE-AVOIDANCE ; BRAIN-STEM ; L. EXTRACT ; RATS ; MICE ; TRANSPORTER
WOS类目Behavioral Sciences ; Neurosciences
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/159956
作者单位1.Ain Shams Univ, Dept Pharmacol & Toxicol, Fac Pharm, Cairo, Egypt;
2.Ain Shams Univ, Dept Biochem, Fac Sci, Cairo, Egypt;
3.Suez Canal Univ, Fac Med, Dept Physiol, Ismailia, Egypt;
4.Ain Shams Univ, Dept Clin Pharm, Fac Pharm, Cairo, Egypt
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GB/T 7714
Tadros, Mariane G.,Mohamed, Mohamed R.,Youssef, Amal M.,等. Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John’s wort-induced prepulse inhibition deficit: A possible role of hyperforin[J],2009,199(2):334-339.
APA Tadros, Mariane G.,Mohamed, Mohamed R.,Youssef, Amal M.,Sabry, Gilane M.,Sabry, Nagwa A.,&Khalifa, Amani E..(2009).Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John’s wort-induced prepulse inhibition deficit: A possible role of hyperforin.BEHAVIOURAL BRAIN RESEARCH,199(2),334-339.
MLA Tadros, Mariane G.,et al."Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John’s wort-induced prepulse inhibition deficit: A possible role of hyperforin".BEHAVIOURAL BRAIN RESEARCH 199.2(2009):334-339.
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