Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.toxicon.2008.07.004 |
Physiological resistance of grasshopper mice (Onychomys spp.) to Arizona bark scorpion (Centruroides exilicauda) venom | |
Rowe, Ashlee H.1; Rowe, Matthew P.2 | |
通讯作者 | Rowe, Ashlee H. |
来源期刊 | TOXICON |
ISSN | 0041-0101 |
出版年 | 2008 |
卷号 | 52期号:5页码:597-605 |
英文摘要 | Predators feeding on toxic prey may evolve physiological resistance to the preys’ toxins. Grasshopper mice (Onychomys spp.) are voracious predators of scorpions in North American deserts. Two species of grasshopper mice (Onychomys torridus and Onychomys arenicola) are broadly sympatric with two species of potentially lethal bark scorpion (Centruroides exilicauda and Centruroides vittatus) in the Sonoran and Chihuahuan deserts, respectively. Bark scorpions produce toxins that selectively bind sodium (Na+) and potassium (K+) ion channels in vertebrate nerve and muscle tissue. We previously reported that grasshopper mice showed no effects of bark scorpion envenomation following natural stings. Here we conducted a series of toxicity tests to determine whether grasshopper mice have evolved resistance to bark scorpion neurotoxins. Five populations of grasshopper mice, either sympatric with or allopatric to bark scorpions, were injected with bark scorpion venom: LD50S were estimated for each population. All five populations of grasshopper mice demonstrated levels of venom resistance greater than that reported for non-resistant Mus musculus. Moreover, venom resistance in the mice showed intra- and interspecific variability that covaried with bark scorpion sympatry and allopatry, patterns consistent with the hypothesis that venom resistance in grasshopper mice is an adaptive response to feeding on their neurotoxic prey. (c) 2008 Elsevier Ltd. All rights reserved. |
英文关键词 | Centruroides Grasshopper mouse Onychomys Predator-prey coevolution Reciprocal selection Scorpion Venom resistance Venom toxicity |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000260756100001 |
WOS关键词 | UP-AND-DOWN ; K+-CHANNELS ; TETRODOTOXIN RESISTANCE ; EVOLUTIONARY RESPONSE ; DANGEROUS PREY ; GARTER SNAKES ; NA+-CHANNELS ; TOXINS ; PEPTIDES ; COEVOLUTION |
WOS类目 | Pharmacology & Pharmacy ; Toxicology |
WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/159304 |
作者单位 | 1.N Carolina State Univ, Dept Zool, Raleigh, NC 27695 USA; 2.Appalachian State Univ, Dept Biol, Boone, NC 28608 USA |
推荐引用方式 GB/T 7714 | Rowe, Ashlee H.,Rowe, Matthew P.. Physiological resistance of grasshopper mice (Onychomys spp.) to Arizona bark scorpion (Centruroides exilicauda) venom[J],2008,52(5):597-605. |
APA | Rowe, Ashlee H.,&Rowe, Matthew P..(2008).Physiological resistance of grasshopper mice (Onychomys spp.) to Arizona bark scorpion (Centruroides exilicauda) venom.TOXICON,52(5),597-605. |
MLA | Rowe, Ashlee H.,et al."Physiological resistance of grasshopper mice (Onychomys spp.) to Arizona bark scorpion (Centruroides exilicauda) venom".TOXICON 52.5(2008):597-605. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。