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DOI10.1055/s-2008-1074503
Induction of mitochondrial-dependent apoptosis by an essential oil from Tanacetum gracile
Verma, Monika1; Singh, Shashank Kumar1; Bhushan, Shashi1; Pal, Harish C.1; Kitchlu, Surinder2; Koul, Maharaj K.2; Thappa, Rajender K.3; Saxena, Ajit K.1
通讯作者Singh, Shashank Kumar
来源期刊PLANTA MEDICA
ISSN0032-0943
出版年2008
卷号74期号:5页码:515-520
英文摘要

The essential oil of Tanacetum gracile (Accession no. AT-01 termed AT-01 in the manuscript), a cold desert alpine highly aromatic herb, has 40 constituents including lavendulol (21.5%), lavendulol acetate (1.7%), alpha-pinene (11.2%),1,8-cineole (15.2%), cis-beta-ocimene (6.9%), borneol (6.1%), limonene (5.1%) and chamazulene (3.7%). AT-01 was evaluated for its anticancer activity. It inhibited HL-60 cell proliferation with an IC(50) of 27 mu g/mL. Furthermore, AT-01 induced apoptosis in human leukemia HL-60 cells as measured by several biological end points. AT-01 induced apoptotic body formation, enhanced annexinV-FITC binding of the cells, increased sub-G(0) DNA fraction, loss of mitochondrial membrane potential (Delta psi(mt)) and release of cytochrome c from mitochondria, activated caspase-9 as well as caspase-3, and increased cleavage of PARP in HL-60 cells. Thus, AT-01 induced apoptosis through the mitochondrial dependant pathway in HL-60 cells.


英文关键词Tanacetum gracile Asteraceae apoptosis essential oil cytotoxicity HL-60
类型Article
语种英语
国家India
收录类别SCI-E
WOS记录号WOS:000255869200006
WOS关键词POLY(ADP-RIBOSE) POLYMERASE ; CYTOCHROME-C ; CELLS ; INHIBITION ; LEUKEMIA ; VULGARE ; RELEASE ; BCL-2
WOS类目Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/158885
作者单位1.Indian Inst Integrat Med, Div Pharmacol, Jammu 180001, India;
2.Indian Inst Integrat Med, Div Bot, Jammu 180001, India;
3.Indian Inst Integrat Med, Div Chem, Jammu 180001, India
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Verma, Monika,Singh, Shashank Kumar,Bhushan, Shashi,et al. Induction of mitochondrial-dependent apoptosis by an essential oil from Tanacetum gracile[J],2008,74(5):515-520.
APA Verma, Monika.,Singh, Shashank Kumar.,Bhushan, Shashi.,Pal, Harish C..,Kitchlu, Surinder.,...&Saxena, Ajit K..(2008).Induction of mitochondrial-dependent apoptosis by an essential oil from Tanacetum gracile.PLANTA MEDICA,74(5),515-520.
MLA Verma, Monika,et al."Induction of mitochondrial-dependent apoptosis by an essential oil from Tanacetum gracile".PLANTA MEDICA 74.5(2008):515-520.
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