干旱区生态环境知识资源中心(Arid): The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria

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DOI	10.1016/j.peptides.2007.07.032
	The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria
	Franssens, Vanessa; Simonet, Gert; Breugelmans, Bert; Van Soest, Sofie; Van Hoef, Vincent; Broeck, Jozef Vanden
通讯作者	Broeck, Jozef Vanden
来源期刊	PEPTIDES
ISSN	0196-9781
出版年	2008
卷号	29 期号:2 页码:235-241
英文摘要	The prophenoloxidase-activating system is an important component of the innate immune response of insects, involved in wound healing and melanotic encapsulation. In this paper we show that in the desert locust, Schistocerca gregaria, hemocytes, challenged with microbial elicitors, are indispensable for the limited proteolytic activation of prophenoloxidase (proPO) in plasma. in addition, we assessed the influence of serine protease inhibitors on the induction of PO-activity in plasma. While soybean Bowman-Birk inhibitor (SBBI) inhibited the PO activation by laminarin-treated hemocytes, the endogenous pacifastin-related inhibitors, SGPI-1 (S. gregaria pacifastin-related inhibitor-1) and SGPI-2 did not affect the PO-activity under similar conditions. On the other hand, real-time PCR analysis revealed that the transcripts, encoding SGPI-1-3, were more abundant in the fat body of immune challenged animals, as compared to control animals. (c) 2007 Elsevier Inc. All rights reserved.
英文关键词	innate immunity phenoloxidase peptide serine protease inhibitor insect hemolymph
类型	Article ; Proceedings Paper
语种	英语
国家	Belgium
收录类别	CPCI-S ; SCI-E
WOS记录号	WOS:000253848400011
WOS关键词	PROTEINASE-INHIBITORS ; MANDUCA-SEXTA ; BACTERIAL LIPOPOLYSACCHARIDE ; OXIDASE ACTIVATION ; NODULE FORMATION ; PURIFICATION ; PEPTIDE ; MIGRATORIA ; HEMOLYMPH ; CASCADE
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/158778
作者单位	Katholieke Univ Leuven, Inst Zool, Dept Anim Physiol & Neurobiol, Lab Dev Physiol Genom & Prot, B-3000 Louvain, Belgium
推荐引用方式 GB/T 7714	Franssens, Vanessa,Simonet, Gert,Breugelmans, Bert,et al. The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria[J],2008,29(2):235-241.
APA	Franssens, Vanessa,Simonet, Gert,Breugelmans, Bert,Van Soest, Sofie,Van Hoef, Vincent,&Broeck, Jozef Vanden.(2008).The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria.PEPTIDES,29(2),235-241.
MLA	Franssens, Vanessa,et al."The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria".PEPTIDES 29.2(2008):235-241.