Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1262/jrd.20054 |
Expression of Hedgehog Family Genes in the Rat Uterus During Early Pregnancy | |
Kubota, Kaiyu1; Yamauchi, Nobuhiko1; Matsumoto, Kenji1; Watanabe, Ryo1; Oozono, Shinji1; Aramaki, Shinya1; Wood, Chris2; Soh, Tomoki1; Hattori, Masa-Aki1 | |
通讯作者 | Yamauchi, Nobuhiko |
来源期刊 | JOURNAL OF REPRODUCTION AND DEVELOPMENT
![]() |
ISSN | 0916-8818 |
出版年 | 2008 |
卷号 | 54期号:5页码:340-345 |
英文摘要 | Hedgehog (Hh) plays a pivotal role in various tissues during embryonic development, tissue homeostasis and tumorigenesis. In mammals, Hh exists in three homologs: Desert hedgehog (Dhh), Indian hedgehog (Ihh) and Sonic hedgehog (Shh). In this Study, we cloned full-length cDNAs encoding Dhh and Ihh from the rat uterus. Their amino acid sequences have a high homology with those of the Mouse and human. In addition, the changes of Hh gene, expression in the rat uterus during early pregnancy were analyzed. The results showed that all three hedgehog mRNAs were detected in the rat uterus at the proestrus stage and during early pregnancy (1.5, 3.5, 5.5 and 7.5 days Post Coitus: dpc). Ihh mRNA expression varied and peaked at 3.5 dpc in the luminal and glandular epithelium. Expression was decreased on 5.5 dpc with the exception Of Sustained expression in the glandular epithelium. Despite such Ihh variability, the expressions of Dhh and Shh mRNA remained unchanged. This indicated that Ihh was mainly expressed ill the rat uterus during early pregnancy. Moreover, the Hh target gene (glioma-associated oncogene homolog 1; Gli1) was also highly expressed at 3.5 dpc in the epithelium and periepithelial stroma in a manner similar to the temporal pattern of Ihh expression. This suggests that Ihh signaling axis play a role in the rat uterus during early pregnancy. In summary, our results elucidate that Hill is a predominant Hh protein in the rat uterus during early pregnancy and that other Hhs have the potential to be expressed. This observation will help to elucidate the basic molecular mechanism of rat uterus during early pregnancy. |
英文关键词 | Hedgehog Implantation Rat Uterus |
类型 | Article |
语种 | 英语 |
国家 | Japan ; Peoples R China |
收录类别 | SCI-E |
WOS记录号 | WOS:000260519200006 |
WOS关键词 | INDIAN-HEDGEHOG ; SONIC HEDGEHOG ; EMBRYO IMPLANTATION ; DESERT HEDGEHOG ; MOUSE UTERUS ; SHH ; IDENTIFICATION ; MORPHOGENESIS ; PATHWAYS ; MEDIATOR |
WOS类目 | Agriculture, Dairy & Animal Science ; Reproductive Biology |
WOS研究方向 | Agriculture ; Reproductive Biology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/158393 |
作者单位 | 1.Kyushu Univ, Grad Sch Agr, Dept Anim & Marine Bioresource Sci, Fukuoka 8128581, Japan; 2.Zhejiang Univ, Coll Life Sci, Inst Cell Biol & Genet, Hangzhou 310058, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Kubota, Kaiyu,Yamauchi, Nobuhiko,Matsumoto, Kenji,et al. Expression of Hedgehog Family Genes in the Rat Uterus During Early Pregnancy[J],2008,54(5):340-345. |
APA | Kubota, Kaiyu.,Yamauchi, Nobuhiko.,Matsumoto, Kenji.,Watanabe, Ryo.,Oozono, Shinji.,...&Hattori, Masa-Aki.(2008).Expression of Hedgehog Family Genes in the Rat Uterus During Early Pregnancy.JOURNAL OF REPRODUCTION AND DEVELOPMENT,54(5),340-345. |
MLA | Kubota, Kaiyu,et al."Expression of Hedgehog Family Genes in the Rat Uterus During Early Pregnancy".JOURNAL OF REPRODUCTION AND DEVELOPMENT 54.5(2008):340-345. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。