干旱区生态环境知识资源中心(Arid): Sesquiterpene Quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert

Arid

DOI	10.1021/np070600c
	Sesquiterpene Quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert
	Wijeratne, E. M. Kithsiri 1; Paranagama, Priyani A.1; Marron, Marilyn T.1; Gunatilaka, Malkanthi K.2; Arnold, A. Elizabeth 2; Gunatilaka, A. A. Leslie 1
通讯作者	Gunatilaka, A. A. Leslie
来源期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
EISSN	1520-6025
出版年	2008
卷号	71 期号:2 页码:218-222
英文摘要	Five new metabolites, (+)-(5S,10S)-4’-hydroxymethylcyclozonarone (1), 3-ketotauranin (3), 3 alpha-hydroxytauranin (4), 12-hydroxytauranin (5), and phyllospinarone (6), together with tauranin (2), were isolated from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis. The structures of the new compounds were determined on the basis of their 1D and 2D NMR spectroscopic data and chemical interconversions. All compounds were evaluated for inhibition of cell proliferation in a panel of five cancer cell lines, and only tauranin (2) showed activity. When tested in a flow cytometry-based assay, tauranin induced apoptosis in PC-3M and NIH 3T3 cell lines.
类型	Article
语种	英语
国家	USA
收录类别	SCI-E
WOS记录号	WOS:000253388000012
WOS关键词	INHIBITORS ; (+)-CYCLOZONARONE ; CONSTITUENTS ; BENZOQUINONE ; DIVERSITY ; TAURANIN ; KINASE
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
来源机构	University of Arizona
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/158336
作者单位	1.Univ Arizona, Coll Agr & Life Sci, SW Ctr Nat Prod Res & Commercializat, Off Arid Lands Studies, Tucson, AZ 85706 USA; 2.Univ Arizona, Coll Agr & Life Sci, Dept Plant Sci, Div Plant Pathol & Microbiol, Tucson, AZ 85721 USA
推荐引用方式 GB/T 7714	Wijeratne, E. M. Kithsiri,Paranagama, Priyani A.,Marron, Marilyn T.,et al. Sesquiterpene Quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert[J]. University of Arizona,2008,71(2):218-222.
APA	Wijeratne, E. M. Kithsiri,Paranagama, Priyani A.,Marron, Marilyn T.,Gunatilaka, Malkanthi K.,Arnold, A. Elizabeth,&Gunatilaka, A. A. Leslie.(2008).Sesquiterpene Quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert.JOURNAL OF NATURAL PRODUCTS,71(2),218-222.
MLA	Wijeratne, E. M. Kithsiri,et al."Sesquiterpene Quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert".JOURNAL OF NATURAL PRODUCTS 71.2(2008):218-222.