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The authors conducted a study in the El Paso, Texas, region to assess the seasonal bioaerosol concentrations in a convenience sample of one-story residences. The authors sampled the same houses for each season over the course of a year (March 2005 to February 2006) to determine bacterial and fungal concentrations, They used a two-stage ambient culturable sampler system to collect the bioaerosol samples. They took indoor and outdoor bioacrosol samples and studied meteorological conditions for each house at each season. The study found that most of the measured bioacrosol concentrations differed statistically by season (P <.05). The greatest concentrations throughout the year were found to occur in fine-sized indoor bacteria during the winter. Meteorological conditions were found not to significantly influence bioacrosol concentrations throughout the year.