Arid
DOI10.1016/j.chroma.2007.11.091
Solving matrix-effects exploiting the second order advantage in the resolution and determination of eight tetracycline antibiotics in effluent wastewater by modelling liquid chromatography data with multivariate curve resolution-alternating least squares and unfolded-partial least squares followed by residual bilinearization algorithms I. Effect of signal pre-treatment
De Zan, M. M.1; Garcia, M. D. Gil2; Culzoni, M. J.1; Siano, R. G.1; Goicoechea, H. C.1; Galera, M. Martinez2
通讯作者Goicoechea, H. C.
来源期刊JOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
EISSN1873-3778
出版年2008
卷号1179期号:2页码:106-114
英文摘要

The effect of piecewise direct standardization (PDS) and baseline correction approaches was evaluated in the performance of multivariate curve resolution (MCR-ALS) algorithm for the resolution of three-way data sets from liquid chromatography with diode-array detection (LC-DAD). First, eight tetracyclines (tetracycline, oxytetracycline, chlorotetracycline, demeclocycline, methacycline, doxycycline, meclocycline and minocycline) were isolated from 250 mL effluent wastewater samples by solid-phase extraction (SPE) with Oasis MAX 500 mg/6 mL cartridges and then separated on an Aquasil C-18 150 mm x 4.6 mm (5 mu m particle size) column by LC and detected by DAD. Previous experiments, carried out with Milli-Q water samples, showed a considerable loss of the most polar analytes (minocycline, oxitetracycline and tetracycline) due to breakthrough. PDS was applied to overcome this important drawback. Conversion of chromatograms obtained from standards prepared in solvent was performed obtaining a high correlation with those corresponding to the real situation (r(2) = 0.98). Although the enrichment and clean-up steps were carefully optimized, the sample matrix caused a large baseline drift, and also additive interferences were present at the retention times of the analytes. These problems were solved with the baseline correction method proposed by Eilers. MCR-ALS was applied to the corrected and uncorrected three-way data sets to obtain spectral and chromatographic profiles of each tetracycline, as well as those corresponding to the co-eluting interferences. The complexity of the calibration model built from uncorrected data sets was higher, as expected, and the quality of the spectral and chromatographic profiles was worse. (C) 2007 Elsevier B.V. All rights reserved.


英文关键词second order data HPLC-DAD wastewater
类型Article
语种英语
国家Argentina ; Spain
收录类别SCI-E
WOS记录号WOS:000253006200005
WOS关键词DIODE-ARRAY DETECTION ; SEQUENTIAL INJECTION-ANALYSIS ; MASS-SPECTROMETRY ; DATA SETS ; MCR-ALS ; FLUORESCENCE ; PARAFAC ; PHOTODEGRADATION ; QUANTIFICATION ; AMOXICILLIN
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/158046
作者单位1.Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, LADAQ, Catedra Quim Analit 1, Santa Fe, Argentina;
2.Univ Almeria, Fac Ciencias Expt, Dept Hidrogeol & Quim Analit, Almeria 04120, Spain
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GB/T 7714
De Zan, M. M.,Garcia, M. D. Gil,Culzoni, M. J.,et al. Solving matrix-effects exploiting the second order advantage in the resolution and determination of eight tetracycline antibiotics in effluent wastewater by modelling liquid chromatography data with multivariate curve resolution-alternating least squares and unfolded-partial least squares followed by residual bilinearization algorithms I. Effect of signal pre-treatment[J],2008,1179(2):106-114.
APA De Zan, M. M.,Garcia, M. D. Gil,Culzoni, M. J.,Siano, R. G.,Goicoechea, H. C.,&Galera, M. Martinez.(2008).Solving matrix-effects exploiting the second order advantage in the resolution and determination of eight tetracycline antibiotics in effluent wastewater by modelling liquid chromatography data with multivariate curve resolution-alternating least squares and unfolded-partial least squares followed by residual bilinearization algorithms I. Effect of signal pre-treatment.JOURNAL OF CHROMATOGRAPHY A,1179(2),106-114.
MLA De Zan, M. M.,et al."Solving matrix-effects exploiting the second order advantage in the resolution and determination of eight tetracycline antibiotics in effluent wastewater by modelling liquid chromatography data with multivariate curve resolution-alternating least squares and unfolded-partial least squares followed by residual bilinearization algorithms I. Effect of signal pre-treatment".JOURNAL OF CHROMATOGRAPHY A 1179.2(2008):106-114.
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