干旱区生态环境知识资源中心(Arid): Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep

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	Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep
	Hassan, Samia A. A.2; Shaddad, Sana A. I.3; Muddathir, A. K.3; El-Tayeb, I. B.4; Nour, A. O. M.5; Al-Nazawi, M. H.1; Homeida, A. M.1
通讯作者	Al-Nazawi, M. H.
来源期刊	JOURNAL OF ANIMAL AND VETERINARY ADVANCES
ISSN	1680-5593
EISSN	1993-601X
出版年	2008
卷号	7 期号:4 页码:433-436
英文摘要	The pharmacokinetics of long-acting Oxytetracycline (OTC) formulation (Alamycin-LA) was studied after intramuscular (IM) route at a dose of 1 mg kg(-1) body weight to fifteen healthy desert sheep. The mean C-max values of 74.8 +/- 13.22 mu g mL(-1) was after 0.9 +/- 0.13 h, the mean distribution phase was 2.0 +/- 0.4 h and the apparent elimination half-life was 126 23 h. The volume of distribution (V-d) was found to be 67.933 +/- 4.88 L. The area under the curve (AUC(240)(0)) and the area under concentration-time curve (AUMC) were 2530.26 +/- 203.3, 242522.2 +/- 48504.5 mu g/ml/h(2), respectively. The total body clearance (cl(beta)) was 373.63 +/- 18,9 mL h(-1) while the mean resident time (MRT) was 90.61 +/- 13.8 h.
英文关键词	Pharmacokinetic intramuscular long-acting oxytetracycline sheep
类型	Article
语种	英语
国家	Saudi Arabia ; Sudan
收录类别	SCI-E
WOS记录号	WOS:000262560600012
WOS关键词	SCREENING-TEST ; TISSUE ; CALVES ; ELIMINATION ; BILIARY ; HENS ; PIGS
WOS类目	Veterinary Sciences
WOS研究方向	Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/157850
作者单位	1.King Faisal Univ, Coll Vet Med & Anim Resources, Al Hasa 31982, Saudi Arabia; 2.Cent Vet Res Lab, Dept Biochem Nutr & Toxicol, Khartoum, Sudan; 3.Univ Khartoum, Fac Pharm, Dept Pharmacol, Khartoum, Sudan; 4.Univ Khartoum, Fac Pharm, Dept Pharmacognosy, Khartoum, Sudan; 5.Univ Khartoum, Fac Pharm, Dept Pharmaceut, Khartoum, Sudan
推荐引用方式 GB/T 7714	Hassan, Samia A. A.,Shaddad, Sana A. I.,Muddathir, A. K.,et al. Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep[J],2008,7(4):433-436.
APA	Hassan, Samia A. A..,Shaddad, Sana A. I..,Muddathir, A. K..,El-Tayeb, I. B..,Nour, A. O. M..,...&Homeida, A. M..(2008).Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep.JOURNAL OF ANIMAL AND VETERINARY ADVANCES,7(4),433-436.
MLA	Hassan, Samia A. A.,et al."Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep".JOURNAL OF ANIMAL AND VETERINARY ADVANCES 7.4(2008):433-436.