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Meatiq and Hafafit core complexes are large swells in the Eastern Desert of Egypt, comprising two major tectono-stratigraphic units or tiers. The lower (infrastructure) unit is composed of variably cataclased gneissose granites and high-grade gneisses and schists. It is structurally overlain by Pan-African ophiolitic melange nappes (the higher unit). The two units are separated by a low-angle sole thrust, along which mylonites are developed. Major and trace element data indicate formation of the gneissose granites in both volcanic are and within-plate settings. Nevertheless, all analyzed gneissose granites and other infrastructural rocks, exhibit low initial ratios (Sr-i) (< 0.7027), positive epsilon(Nd)(t) (+4.9 to +10.3) and Neoproterozoic Nd model age (T-DM) (592-831 Ma for the gneissose granite samples). Although these values are compatible with other parts of the Arabian- Nubian Shield considered to be juvenile, the epsilon(Nd)(t) values and several incompatible element ratios of the gneissose granites are too low to be derived from a mantle source without contribution from an older continental crust. Our geological, Sr-Nd isotopic and chemical data combined with the published zircon ages indicate the existence of a pre-Neoproterozoic continent in the Eastern Desert that started to break up at ca 800 Ma. Rifting and subsequent events caused the formation of oceanic crust and emplacement within-plate alkali basalts in the hinterland domains of the old continent. The emplacement of basaltic magma might have triggered melting of lower crust in the old continent and resulted in emplacement of the within-plate granite masses between 700 Ma and 626 Ma. The granite masses and other rocks in the old continent have been subjected to deformation during the over-thrusting of Pan-African nappes, probably because of the oblique convergence between East and West Gondwanaland. Rb-Sr isotopes of the gneissose granites in both Meatiq and Hafafit core complexes defines an isochron age of 619 +/- 25 Ma with Sri of 0.7009 +/- 0.0017 and mean squares of weighted deviates = 2.0. We interpret this age as the date of thrusting of the Pan-African nappes in the Eastern Desert. Continued oblique convergence between East and West Gondwanaland could have resulted in the formation northwest-southeast-trending Meatiq and Hafafit anticlinoriums.