Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.chembiol.2008.10.006 |
Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii | |
Wang, Shuhao1; Xu, Yuquan1; Maine, Erin A.1; Wijeratne, E. M. Kithsiri1; Espinosa-Artiles, Patricia1; Gunatilaka, A. A. Leslie1,2; Molnar, Istvan1,2 | |
通讯作者 | Molnar, Istvan |
来源期刊 | CHEMISTRY & BIOLOGY
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ISSN | 1074-5521 |
EISSN | 1879-1301 |
出版年 | 2008 |
卷号 | 15期号:12页码:1328-1338 |
英文摘要 | Fungal polyketides with the resorcylic acid lactone (RAL) scaffold are of interest for growth stimulation, the treatment of cancer, and neurodegenerative diseases. The RAL radicicol is a nanomolar inhibitor of the chaperone Hsp90, whose repression leads to a combinatorial blockade of cancer-causing pathways. Clustered genes for radicicol biosynthesis were identified and functionally characterized from the endophytic fungus Chaetomium chiversii, and compared to recently described RAL biosynthetic gene clusters. Radicicol production is abolished upon targeted inactivation of a putative cluster-specific regulator, or either of the two polyketide synthases that are predicted to collectively synthesize the radicicol polyketide core. Genomic evidence supports the existence of flavin-dependent halogenases in fungi: inactivation of such a putative halogenase from the C. chiversii radicicol locus yields dechloro-radicicol (monocillin I). Inactivation of a cytochrome P450 epoxidase furnishes pochonin D, a deepoxy-dihydro radicicol analog. |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000262089600011 |
WOS关键词 | FUNGAL POLYKETIDE SYNTHASE ; DOUBLE-BOND FORMATION ; GIBBERELLA-ZEAE ; GENE-CLUSTER ; POCHONIA-CHLAMYDOSPORIA ; MOLECULAR CHAPERONE ; CARRIER PROTEIN ; SONORAN-DESERT ; IDENTIFICATION ; HALOGENATION |
WOS类目 | Biochemistry & Molecular Biology |
WOS研究方向 | Biochemistry & Molecular Biology |
来源机构 | University of Arizona |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/156818 |
作者单位 | 1.Univ Arizona, SW Ctr Nat Prod Res & Commercializat, Off Arid Lands Studies, Tucson, AZ 85706 USA; 2.Univ Arizona, Inst Bio5, Tucson, AZ 85721 USA |
推荐引用方式 GB/T 7714 | Wang, Shuhao,Xu, Yuquan,Maine, Erin A.,et al. Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii[J]. University of Arizona,2008,15(12):1328-1338. |
APA | Wang, Shuhao.,Xu, Yuquan.,Maine, Erin A..,Wijeratne, E. M. Kithsiri.,Espinosa-Artiles, Patricia.,...&Molnar, Istvan.(2008).Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii.CHEMISTRY & BIOLOGY,15(12),1328-1338. |
MLA | Wang, Shuhao,et al."Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii".CHEMISTRY & BIOLOGY 15.12(2008):1328-1338. |
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