Arid
DOI10.1016/j.ajhg.2008.03.015
Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women’s genome health study
Ridker, Paul M.1,2; Pare, Guillaume1; Parker, Alex3; Zee, Robert Y. L.1,2; Danik, Jacqueline S.1,2; Buring, Julie E.1; Kwiatkowski, David2; Cook, Nancy R.1,2; Miletich, Joseph P.3; Chasman, Daniel I.1,2
通讯作者Ridker, Paul M.
来源期刊AMERICAN JOURNAL OF HUMAN GENETICS
ISSN0002-9297
出版年2008
卷号82期号:5页码:1185-1192
英文摘要

Although elevated levels of C-reactive protein (CRP) independently predict increased risk of development of metabolic syndrome, diabetes, myocardial infarction, and stroke, comprehensive analysis of the influence of genetic variation on CRP is not available. To address this issue, we performed a genome-wide association study among 6345 apparently healthy women in which we evaluated 336,108 SNPs as potential determinants of plasma CRP concentration. Overall, seven loci that associate with plasma CRP at levels achieving genome-wide statistical significance were found (range of p values for lead SNPs within the seven loci: 1.9 x 10(-8) to 6.2 x 10(-28)). Two of these loci (GCKR and HNF1A) are suspected or known to be associated with maturity-onset diabetes of the young, one is a gene-desert region on 12q23.2, and the remaining four loci are in or near the leptin receptor protein gene, the apolipoprotein E gene, the interleukin-6 receptor protein gene, or the CRP gene itself. The protein products of six of these seven loci are directly involved in metabolic syndrome, insulin resistance, beta cell function, weight homeostasis, and/or premature atherothrombosis. Thus, common variation in several genes involved in metabolic and inflammatory regulation have significant effects on CRP levels, consistent with CRP’s identification as a useful biomarker of risk for incident vascular disease and diabetes.


类型Article
语种英语
国家USA
收录类别SCI-E
WOS记录号WOS:000255923600019
WOS关键词APOLIPOPROTEIN-E GENOTYPES ; TYPE-2 DIABETES-MELLITUS ; CARDIOVASCULAR-DISEASE ; GENE POLYMORPHISMS ; SOLUBLE RECEPTOR ; CRP LEVELS ; RISK ; INTERLEUKIN-6 ; EVENTS ; LEPTIN
WOS类目Genetics & Heredity
WOS研究方向Genetics & Heredity
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/156350
作者单位1.Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Cardiovasc Dis Prevent, Boston, MA 02115 USA;
2.Harvard Univ, Sch Med, Brigham & Womens Hosp, Donald W Reynolds Ctr Cardiovasc Res, Boston, MA 02115 USA;
3.Amgen Inc, Cambridge, MA 02139 USA
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GB/T 7714
Ridker, Paul M.,Pare, Guillaume,Parker, Alex,等. Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women’s genome health study[J],2008,82(5):1185-1192.
APA Ridker, Paul M..,Pare, Guillaume.,Parker, Alex.,Zee, Robert Y. L..,Danik, Jacqueline S..,...&Chasman, Daniel I..(2008).Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women’s genome health study.AMERICAN JOURNAL OF HUMAN GENETICS,82(5),1185-1192.
MLA Ridker, Paul M.,et al."Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women’s genome health study".AMERICAN JOURNAL OF HUMAN GENETICS 82.5(2008):1185-1192.
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