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DOI | 10.1016/j.ajhg.2008.03.015 |
Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women’s genome health study | |
Ridker, Paul M.1,2; Pare, Guillaume1; Parker, Alex3; Zee, Robert Y. L.1,2; Danik, Jacqueline S.1,2; Buring, Julie E.1; Kwiatkowski, David2; Cook, Nancy R.1,2; Miletich, Joseph P.3; Chasman, Daniel I.1,2 | |
通讯作者 | Ridker, Paul M. |
来源期刊 | AMERICAN JOURNAL OF HUMAN GENETICS
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ISSN | 0002-9297 |
出版年 | 2008 |
卷号 | 82期号:5页码:1185-1192 |
英文摘要 | Although elevated levels of C-reactive protein (CRP) independently predict increased risk of development of metabolic syndrome, diabetes, myocardial infarction, and stroke, comprehensive analysis of the influence of genetic variation on CRP is not available. To address this issue, we performed a genome-wide association study among 6345 apparently healthy women in which we evaluated 336,108 SNPs as potential determinants of plasma CRP concentration. Overall, seven loci that associate with plasma CRP at levels achieving genome-wide statistical significance were found (range of p values for lead SNPs within the seven loci: 1.9 x 10(-8) to 6.2 x 10(-28)). Two of these loci (GCKR and HNF1A) are suspected or known to be associated with maturity-onset diabetes of the young, one is a gene-desert region on 12q23.2, and the remaining four loci are in or near the leptin receptor protein gene, the apolipoprotein E gene, the interleukin-6 receptor protein gene, or the CRP gene itself. The protein products of six of these seven loci are directly involved in metabolic syndrome, insulin resistance, beta cell function, weight homeostasis, and/or premature atherothrombosis. Thus, common variation in several genes involved in metabolic and inflammatory regulation have significant effects on CRP levels, consistent with CRP’s identification as a useful biomarker of risk for incident vascular disease and diabetes. |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000255923600019 |
WOS关键词 | APOLIPOPROTEIN-E GENOTYPES ; TYPE-2 DIABETES-MELLITUS ; CARDIOVASCULAR-DISEASE ; GENE POLYMORPHISMS ; SOLUBLE RECEPTOR ; CRP LEVELS ; RISK ; INTERLEUKIN-6 ; EVENTS ; LEPTIN |
WOS类目 | Genetics & Heredity |
WOS研究方向 | Genetics & Heredity |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/156350 |
作者单位 | 1.Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Cardiovasc Dis Prevent, Boston, MA 02115 USA; 2.Harvard Univ, Sch Med, Brigham & Womens Hosp, Donald W Reynolds Ctr Cardiovasc Res, Boston, MA 02115 USA; 3.Amgen Inc, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Ridker, Paul M.,Pare, Guillaume,Parker, Alex,等. Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women’s genome health study[J],2008,82(5):1185-1192. |
APA | Ridker, Paul M..,Pare, Guillaume.,Parker, Alex.,Zee, Robert Y. L..,Danik, Jacqueline S..,...&Chasman, Daniel I..(2008).Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women’s genome health study.AMERICAN JOURNAL OF HUMAN GENETICS,82(5),1185-1192. |
MLA | Ridker, Paul M.,et al."Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The women’s genome health study".AMERICAN JOURNAL OF HUMAN GENETICS 82.5(2008):1185-1192. |
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