Arid
DOI10.1038/ng2061
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility
Parkes, Miles; Barrett, Jeffrey C.; Prescott, Natalie J.; Tremelling, Mark; Anderson, Carl A.; Fisher, Sheila A.; Roberts, Roland G.; Nimmo, Elaine R.; Cummings, Fraser R.; Soars, Dianne; Drummond, Hazel; Lees, Charlie W.; Khawaja, Saud A.; Bagnall, Richard; Burke, Denis A.; Todhunter, Catherine E.; Ahmad, Tariq; Onnie, Clive M.; McArdle, Wendy; Strachan, David; Bethel, Graeme; Bryan, Claire; Lewis, Cathryn M.; Deloukas, Panos; Forbes, Alastair; Sanderson, Jeremy; Jewell, Derek P.; Satsangi, Jack; Mansfield, John C.; Cardon, Lon; Mathew, Christopher G.
通讯作者Parkes, Miles
来源期刊NATURE GENETICS
ISSN1061-4036
出版年2007
卷号39期号:7页码:830-832
英文摘要

A genome- wide association scan in individuals with Crohn’s disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13.


类型Article
语种英语
国家England ; Scotland
收录类别SCI-E
WOS记录号WOS:000247619800010
WOS关键词GENOME-WIDE ASSOCIATION ; RESISTANCE ; EXPRESSION ; IL23R
WOS类目Genetics & Heredity
WOS研究方向Genetics & Heredity
来源机构University of London ; University of Oxford
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/155478
作者单位(1)Addenbrookes Hosp, Inflammatory Bowel Dis Res Grp, Cambridge CB2 2QQ, England;(2)Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England;(3)Kings Coll London, Guys Hosp, Sch Med, Dept Med & Mol Genet, London SE1 9RT, England;(4)Univ Edinburgh, Western Gen Hosp, Sch Mol & Clin Med, Div Med Sci,Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland;(5)Univ Oxford, Radcliffe Infirm, Gastroenterol Unit, Oxford OX2 6HE, England;(6)Univ Newcastle Upon Tyne, Royal Victoria Infirm, Dept Gastroenterol & Hepatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England;(7)Univ Bristol, ALSPAC, Bristol BS8 1TQ, Avon, England;(8)St Georges Univ London, Div Community Hlth Serv, London SW17 0RE, England;(9)Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England;(10)UCL, Hosp Trust, Inst Digest Dis, London NW1 2BU, England;(11)Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, England
推荐引用方式
GB/T 7714
Parkes, Miles,Barrett, Jeffrey C.,Prescott, Natalie J.,等. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility[J]. University of London, University of Oxford,2007,39(7):830-832.
APA Parkes, Miles.,Barrett, Jeffrey C..,Prescott, Natalie J..,Tremelling, Mark.,Anderson, Carl A..,...&Mathew, Christopher G..(2007).Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility.NATURE GENETICS,39(7),830-832.
MLA Parkes, Miles,et al."Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility".NATURE GENETICS 39.7(2007):830-832.
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