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DOI | 10.1038/ng2061 |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility | |
Parkes, Miles; Barrett, Jeffrey C.; Prescott, Natalie J.; Tremelling, Mark; Anderson, Carl A.; Fisher, Sheila A.; Roberts, Roland G.; Nimmo, Elaine R.; Cummings, Fraser R.; Soars, Dianne; Drummond, Hazel; Lees, Charlie W.; Khawaja, Saud A.; Bagnall, Richard; Burke, Denis A.; Todhunter, Catherine E.; Ahmad, Tariq; Onnie, Clive M.; McArdle, Wendy; Strachan, David; Bethel, Graeme; Bryan, Claire; Lewis, Cathryn M.; Deloukas, Panos; Forbes, Alastair; Sanderson, Jeremy; Jewell, Derek P.; Satsangi, Jack; Mansfield, John C.; Cardon, Lon; Mathew, Christopher G. | |
通讯作者 | Parkes, Miles |
来源期刊 | NATURE GENETICS
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ISSN | 1061-4036 |
出版年 | 2007 |
卷号 | 39期号:7页码:830-832 |
英文摘要 | A genome- wide association scan in individuals with Crohn’s disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13. |
类型 | Article |
语种 | 英语 |
国家 | England ; Scotland |
收录类别 | SCI-E |
WOS记录号 | WOS:000247619800010 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; RESISTANCE ; EXPRESSION ; IL23R |
WOS类目 | Genetics & Heredity |
WOS研究方向 | Genetics & Heredity |
来源机构 | University of London ; University of Oxford |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/155478 |
作者单位 | (1)Addenbrookes Hosp, Inflammatory Bowel Dis Res Grp, Cambridge CB2 2QQ, England;(2)Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England;(3)Kings Coll London, Guys Hosp, Sch Med, Dept Med & Mol Genet, London SE1 9RT, England;(4)Univ Edinburgh, Western Gen Hosp, Sch Mol & Clin Med, Div Med Sci,Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland;(5)Univ Oxford, Radcliffe Infirm, Gastroenterol Unit, Oxford OX2 6HE, England;(6)Univ Newcastle Upon Tyne, Royal Victoria Infirm, Dept Gastroenterol & Hepatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England;(7)Univ Bristol, ALSPAC, Bristol BS8 1TQ, Avon, England;(8)St Georges Univ London, Div Community Hlth Serv, London SW17 0RE, England;(9)Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England;(10)UCL, Hosp Trust, Inst Digest Dis, London NW1 2BU, England;(11)Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, England |
推荐引用方式 GB/T 7714 | Parkes, Miles,Barrett, Jeffrey C.,Prescott, Natalie J.,等. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility[J]. University of London, University of Oxford,2007,39(7):830-832. |
APA | Parkes, Miles.,Barrett, Jeffrey C..,Prescott, Natalie J..,Tremelling, Mark.,Anderson, Carl A..,...&Mathew, Christopher G..(2007).Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility.NATURE GENETICS,39(7),830-832. |
MLA | Parkes, Miles,et al."Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility".NATURE GENETICS 39.7(2007):830-832. |
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