Arid
DOI10.1038/nature05805
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
Mikkelsen, Tarjei S.; Wakefield, Matthew J.; Aken, Bronwen; Amemiya, Chris T.; Chang, Jean L.; Duke, Shannon; Garber, Manuel; Gentles, Andrew J.; Goodstadt, Leo; Heger, Andreas; Jurka, Jerzy; Kamal, Michael; Mauceli, Evan; Searle, Stephen M. J.; Sharpe, Ted; Baker, Michelle L.; Batzer, Mark A.; Benos, Panayiotis V.; Belov, Katherine; Clamp, Michele; Cook, April; Cuff, James; Das, Radhika; Davidow, Lance; Deakin, Janine E.; Fazzari, Melissa J.; Glass, Jacob L.; Grabherr, Manfred; Greally, John M.; Gu, Wanjun; Hore, Timothy A.; Huttley, Gavin A.; Kleber, Michael; Jirtle, Randy L.; Koina, Edda; Lee, Jeannie T.; Mahony, Shaun; Marra, Marco A.; Miller, Robert D.; Nicholls, Robert D.; Oda, Mayumi; Papenfuss, Anthony T.; Parra, Zuly E.; Pollock, David D.; Ray, David A.; Schein, Jacqueline E.; Speed, Terence P.; Thompson, Katherine; VandeBerg, John L.; Wade, Claire M.; Walker, Jerilyn A.; Waters, Paul D.; Webber, Caleb; Weidman, Jennifer R.; Xie, Xiaohui; Zody, Michael C.; Graves, Jennifer A. Marshall; Ponting, Chris P.; Breen, Matthew; Samollow, Paul B.; Lander, Eric S.; Lindblad-Toh, Kerstin
通讯作者Lindblad-Toh, Kerstin
来源期刊NATURE
ISSN0028-0836
出版年2007
卷号447期号:7141页码:167-U1
英文摘要

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum ( Monodelphis domestica). As the first metatherian (’marsupial’) species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.


类型Review
语种英语
国家USA ; Australia ; England ; Canada
收录类别SCI-E
WOS记录号WOS:000246338700035
WOS关键词X-CHROMOSOME INACTIVATION ; SHORT-TAILED OPOSSUM ; RECOMBINATION RATES ; TRANSPOSABLE ELEMENTS ; VERTEBRATE EVOLUTION ; REGULATORY NETWORKS ; MAMMALIAN EVOLUTION ; MOBILE ELEMENTS ; GENE DESERTS ; MOUSE
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
来源机构University of Oxford
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/155474
作者单位(1)MIT, Broad Inst, Cambridge, MA 02142 USA;(2)Harvard Univ, Cambridge, MA 02142 USA;(3)MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA;(4)Walter & Eliza Hall Inst Med Res, Bioinformat Div, Parkville, Vic 3050, Australia;(5)Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England;(6)Benaroya Res Inst Virginia Mason, Mol Genet Program, Seattle, WA 98101 USA;(7)N Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC 27606 USA;(8)Stanford Univ, Sch Med, Stanford, CA 94305 USA;(9)Genet Informat Res Inst, Mountain View, CA 94043 USA;(10)Univ Oxford, MRC Funct Genet Unit, Dept Physiol Anat & Genet, Oxford OX1 3QX, England;(11)Univ New Mexico, Ctr Evolutionary & Theoret Immunol, Dept Biol, Albuquerque, NM 87131 USA;(12)Louisiana State Univ, Ctr Biomodular Multiscale Syst, Dept Biol Sci, Biol Computat & Visualizat Ctr, Baton Rouge, LA 70803 USA;(13)Univ Pittsburgh, Dept Computat Biol, Pittsburgh, PA 15260 USA;(14)Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia;(15)Duke Univ, Med Ctr, Dept ...
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Mikkelsen, Tarjei S.,Wakefield, Matthew J.,Aken, Bronwen,et al. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences[J]. University of Oxford,2007,447(7141):167-U1.
APA Mikkelsen, Tarjei S..,Wakefield, Matthew J..,Aken, Bronwen.,Amemiya, Chris T..,Chang, Jean L..,...&Lindblad-Toh, Kerstin.(2007).Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.NATURE,447(7141),167-U1.
MLA Mikkelsen, Tarjei S.,et al."Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences".NATURE 447.7141(2007):167-U1.
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