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DOI | 10.1016/j.chroma.2006.11.024 |
Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues | |
Wu, Yujie; Yu, Huan; Wang, Yulian; Huang, Lingli; Tao, Yanfei; Chen, Dongmei; Peng, Dapeng; Liu, Zhengli; Yuan, Zonghui | |
通讯作者 | Yuan, Zonghui |
来源期刊 | JOURNAL OF CHROMATOGRAPHY A
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ISSN | 0021-9673 |
出版年 | 2007 |
卷号 | 1146期号:1页码:1-7 |
英文摘要 | A method of high-performance liquid chromatography with UV detection has been established for simultaneous quantitative determination of quinoxaline-2-carboxylic acid (QCA) and methyl-3-quinoxaline-2-carboxylic acid (MQCA), the marker residues for carbadox (CBX) and olaquindox (OLA), respectively, in the muscles and livers of porcine and chicken and in the muscle of fish. Tissue samples were subject to acid hydrolysis followed by liquid-liquid extraction and Oasis MAX solid-phase extraction clean-up. The method was validated according to the EU Commission Decision 2002/657/EC. The decision limits (CC alpha) were 0.7-2.6 mu g/kg and the detection capabilities (CC beta) were 1.3-5.6 mu g/kg for QCA and MQCA in tissues. The recoveries of QCA and MQCA, spiked at levels of 2-100 mu g/kg, were from 70 to 110%; the relative standard deviation values were < 20%. This simple, fast and economic method could be applied to the monitoring for the possible misuse of CBX and OLA in animal edible tissue samples. (c) 2006 Elsevier B.V. All rights reserved. |
英文关键词 | carbadox olaquindox quinoxaline-2-carboxylic acid methyl-3-quinoxaline-2-carboxylic acid animal edible tissues residues HPLC |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
收录类别 | SCI-E |
WOS记录号 | WOS:000245383200001 |
WOS关键词 | PORCINE LIVER ; MASS-SPECTROMETRY ; CARBADOX ; METABOLITE ; CONFIRMATION ; ELECTROSPRAY ; GROWTH ; PIGS |
WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/154883 |
作者单位 | (1)Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, MOA Key Lab Food Safety Evaluat, Wuhan 430070, Peoples R China |
推荐引用方式 GB/T 7714 | Wu, Yujie,Yu, Huan,Wang, Yulian,et al. Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues[J],2007,1146(1):1-7. |
APA | Wu, Yujie.,Yu, Huan.,Wang, Yulian.,Huang, Lingli.,Tao, Yanfei.,...&Yuan, Zonghui.(2007).Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues.JOURNAL OF CHROMATOGRAPHY A,1146(1),1-7. |
MLA | Wu, Yujie,et al."Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues".JOURNAL OF CHROMATOGRAPHY A 1146.1(2007):1-7. |
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