Arid
DOI10.1016/j.chroma.2006.11.024
Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues
Wu, Yujie; Yu, Huan; Wang, Yulian; Huang, Lingli; Tao, Yanfei; Chen, Dongmei; Peng, Dapeng; Liu, Zhengli; Yuan, Zonghui
通讯作者Yuan, Zonghui
来源期刊JOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
出版年2007
卷号1146期号:1页码:1-7
英文摘要

A method of high-performance liquid chromatography with UV detection has been established for simultaneous quantitative determination of quinoxaline-2-carboxylic acid (QCA) and methyl-3-quinoxaline-2-carboxylic acid (MQCA), the marker residues for carbadox (CBX) and olaquindox (OLA), respectively, in the muscles and livers of porcine and chicken and in the muscle of fish. Tissue samples were subject to acid hydrolysis followed by liquid-liquid extraction and Oasis MAX solid-phase extraction clean-up. The method was validated according to the EU Commission Decision 2002/657/EC. The decision limits (CC alpha) were 0.7-2.6 mu g/kg and the detection capabilities (CC beta) were 1.3-5.6 mu g/kg for QCA and MQCA in tissues. The recoveries of QCA and MQCA, spiked at levels of 2-100 mu g/kg, were from 70 to 110%; the relative standard deviation values were < 20%. This simple, fast and economic method could be applied to the monitoring for the possible misuse of CBX and OLA in animal edible tissue samples. (c) 2006 Elsevier B.V. All rights reserved.


英文关键词carbadox olaquindox quinoxaline-2-carboxylic acid methyl-3-quinoxaline-2-carboxylic acid animal edible tissues residues HPLC
类型Article
语种英语
国家Peoples R China
收录类别SCI-E
WOS记录号WOS:000245383200001
WOS关键词PORCINE LIVER ; MASS-SPECTROMETRY ; CARBADOX ; METABOLITE ; CONFIRMATION ; ELECTROSPRAY ; GROWTH ; PIGS
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/154883
作者单位(1)Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, MOA Key Lab Food Safety Evaluat, Wuhan 430070, Peoples R China
推荐引用方式
GB/T 7714
Wu, Yujie,Yu, Huan,Wang, Yulian,et al. Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues[J],2007,1146(1):1-7.
APA Wu, Yujie.,Yu, Huan.,Wang, Yulian.,Huang, Lingli.,Tao, Yanfei.,...&Yuan, Zonghui.(2007).Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues.JOURNAL OF CHROMATOGRAPHY A,1146(1),1-7.
MLA Wu, Yujie,et al."Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues".JOURNAL OF CHROMATOGRAPHY A 1146.1(2007):1-7.
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