Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.2116/bunsekikagaku.56.317 |
Simultaneous determination of residual veterinary drugs in muscle by on-line solid phase extraction/high-performance liquid chromatography/tandem mass spectrometry | |
Tagiri-Endo, Misako; Yanagita, Noriaki | |
通讯作者 | Tagiri-Endo, Misako |
来源期刊 | BUNSEKI KAGAKU
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ISSN | 0525-1931 |
出版年 | 2007 |
卷号 | 56期号:5页码:317-326 |
英文摘要 | A rapid simultaneous assay was developed for determining 63 veterinary drugs in bovine, porcine, and poultry muscles by on-line solid phase extraction (on-line SPE)/high-performance liquid chromatography/tandem mass spectrometry (MS/MS). The drugs were extracted from muscle samples with acetonitrile-methanol (4: 1, v/v). The extracts were evaporated, and the residues were dissolved with acetonitrile-water (I : 1, v/v). The samples were injected into an on-line SPE column packed with Oasis HLB using 0.1% formic acid as a mobile phase, to separate drugs from interfering substances and retain them on it. The drugs were introduced onto an analytical column using 0.1% formic acid-acetonitrile in a gradient mode by column switching and directed into MS/MS. Under the optimal analytical conditions, the repeatability of the retention time and the peak area of standard compounds were less than 1% and 12%, respectively. The recoveries of 63 drugs from muscle spiked at 20 ng/g were 45.8 similar to 153%. The detection limits were less than or equal to 10 ng/g. |
英文关键词 | veterinary drugs LC/MS/MS on-line solid phase extraction column switching muscle |
类型 | Article |
语种 | Japanese |
国家 | Japan |
收录类别 | SCI-E |
WOS记录号 | WOS:000246718400003 |
WOS关键词 | BOVINE-MILK ; CLEANUP ; COLUMN |
WOS类目 | Chemistry, Analytical |
WOS研究方向 | Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/153731 |
作者单位 | (1)Miyagi Prefectural Govt, Inst Publ Hlth & Environm, Miyagino Ku, Sendai, Miyagi 9838666, Japan |
推荐引用方式 GB/T 7714 | Tagiri-Endo, Misako,Yanagita, Noriaki. Simultaneous determination of residual veterinary drugs in muscle by on-line solid phase extraction/high-performance liquid chromatography/tandem mass spectrometry[J],2007,56(5):317-326. |
APA | Tagiri-Endo, Misako,&Yanagita, Noriaki.(2007).Simultaneous determination of residual veterinary drugs in muscle by on-line solid phase extraction/high-performance liquid chromatography/tandem mass spectrometry.BUNSEKI KAGAKU,56(5),317-326. |
MLA | Tagiri-Endo, Misako,et al."Simultaneous determination of residual veterinary drugs in muscle by on-line solid phase extraction/high-performance liquid chromatography/tandem mass spectrometry".BUNSEKI KAGAKU 56.5(2007):317-326. |
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