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Devils Hole is a collapse depression connected to the regional carbonate aquifer of the Death Valley ground water flow system. Devils Hole pool is home to an endangered pupfish that was threatened when irrigation pumping in nearby Ash Meadows lowered the pool stage in the 1960s. Pumping at Ash Meadows ultimately ceased, and the stage recovered until 1988, when it began to decline, a trend that continued until at least 2004. Regional ground water pumping and changes in recharge are considered the principal potential stresses causing long term stage changes. A regression was found between pumpage and Devils Hole water levels. Though precipitation in distant mountain ranges is the source of recharge to the flow system, the stage of Devils Hole shows small change in stage from 1937 to 1963, a period during which ground water withdrawals were small and the major stress on stage would have been recharge. Multiple regression analyses, made by including the cumulative departure from normal precipitation with pumpage as independent variables, did not improve the regression. Drawdown at Devils Hole was calculated by the Theis Equation for nearby pumping centers to incorporate time delay and drawdown attenuation. The Theis drawdowns were used as surrogates for pumpage in multiple regression analyses. The model coefficient for the regression, R-2 = 0.982, indicated that changes in Devils Hole were largely due to effects of pumping at Ash Meadows, Amargosa Desert, and Army 1.