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DOI10.1111/j.1471-4159.2005.03596.x
Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress
Murakami, T; Kondo, S; Ogata, M; Kanemoto, S; Saito, A; Wanaka, A; Imaizumi, K
通讯作者Imaizumi, K
来源期刊JOURNAL OF NEUROCHEMISTRY
ISSN0022-3042
EISSN1471-4159
出版年2006
卷号96期号:4页码:1090-1100
英文摘要

When unfolded or misfolded proteins accumulate in the endoplasmic reticulum (ER), unfolded protein response (UPR) signals are transmitted from the ER to the nucleus and cytoplasm to facilitate protein folding. OASIS (old astrocyte specifically induced substance) is an ER stress transducer in astrocytes, a membrane-bound transcription factor that activates genes in the ER stress response. When unfolded proteins accumulate in the ER, OASIS is cleaved at the membrane to release its cytoplasmic domain, which then enters the nucleus and activates target genes. Here, we showed that OASIS is processed by Site-1 and -2 proteases (S1P and S2P), enzymes that reside at the Golgi apparatus and process activating transcription factor 6 (ATF6) in response to ER stress. We also showed that the cleavage of OASIS is triggered by its translocation to the Golgi apparatus. All deletion mutants for luminal domain of OASIS showed that proteolytic processing and translocation to the Golgi apparatus remained intact, indicating that OASIS does not have significant sequences for Golgi localization signals, different from the case of ATF6, and that there could be other systems for translocation of OASIS to the Golgi apparatus in response to ER stress.


英文关键词endoplasmic reticulum stress old astrocyte specifically induced substance regulated intramembrane proteolysis transcription factor unfolded protein response
类型Article
语种英语
国家Japan
收录类别SCI-E
WOS记录号WOS:000234975200018
WOS关键词REGULATED INTRAMEMBRANE PROTEOLYSIS ; ELEMENT-BINDING PROTEINS ; ER STRESS ; ACTIVATING PROTEIN ; SITE-1 PROTEASE ; SREBPS ; GOLGI ; ATF6 ; IDENTIFICATION ; TRANSPORT
WOS类目Biochemistry & Molecular Biology ; Neurosciences
WOS研究方向Biochemistry & Molecular Biology ; Neurosciences & Neurology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/152291
作者单位(1)Miyazaki Univ, Div Mol & Cellular Biol, Dept Anat, Fac Med, Kiyotake, Miyazaki 8891692, Japan;(2)Nara Inst Sci & Technol, Div Struct Cellular Biol, Nara, Japan;(3)Nara Med Univ, Dept Anat, Kashihara, Nara 634, Japan
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GB/T 7714
Murakami, T,Kondo, S,Ogata, M,et al. Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress[J],2006,96(4):1090-1100.
APA Murakami, T.,Kondo, S.,Ogata, M.,Kanemoto, S.,Saito, A.,...&Imaizumi, K.(2006).Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress.JOURNAL OF NEUROCHEMISTRY,96(4),1090-1100.
MLA Murakami, T,et al."Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress".JOURNAL OF NEUROCHEMISTRY 96.4(2006):1090-1100.
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