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Ecomorphometric markers reflect quantitative variations in the potent antifeedant, azadirachtin-A from neem. Fifty accessions from five ecogeographically distinct regions in Andhra Pradesh, India were studied. Significant disparity in azadirachtin-A density, 100 seed weight and total azadirachtin-A was observed in accessions between the extremely-arid-alkaline and deltawet regions. Statistical tools such as Linear Multiple Regression Analysis, Duncan’s New Multiple Range Test and Pearson Correlation were used to find out the relationship between independent variables (leaf, fruit/seed and soil parameters) and dependent variables (azadirachtin-A density and total azadirachtin-A content).