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This paper describes a gas chromatography-mass spectrometry method for the simultaneous detection of opiates, cocaine, and benzoylecgonine from human hair samples. Conditioning samples were extracted with Waters Oasis HLB (hydrophilic-lipophilic balance) cartridges. The detector response was linear for the drugs studied over the range 0.5 - 20 ng/mg. The limits of quantitation and detection were found to be acceptable. Intra- and interbatch coefficients of variation oscillated between 0.2 and 17.9%, and mean relative errors were in the range of 0.04 - 18.2%. The recoveries were higher than 66.7% in all cases. Finally, the method was applied to 20 hair samples from drug users, obtaining positive results in all cases.