Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.toxicon.2004.11.005 |
Acute intoxication by Crotalaria retusa in sheep | |
Nobre, VMT; Dantas, AFM; Riet-Correa, F; Barbosa, JM; Tabosa, IM; Vasconcelos, JS | |
通讯作者 | Riet-Correa, F |
来源期刊 | TOXICON
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ISSN | 0041-0101 |
出版年 | 2005 |
卷号 | 45期号:3页码:347-352 |
英文摘要 | Acute intoxication by seeding Crotalaria retusa occurred during the dry season, in a flock of 80 sheep, in the semi-arid region of the state of Paraiba, northeastern Brazil. Anorexia, severe depression, mild jaundice, incoordination and recumbence were observed in 16 sheep that died within 12 h. At necropsy the liver had a nutmeg appearance. Seeds of C. retusa were found in large amounts in the rumen of the dead animals. Histologic lesions of the liver were characterized by centrilobular necrosis. Seeds of C. retusa were given to six sheep at doses of 2.5 (two sheep), 5, 10, 20 and 40 g/kg bw (one sheep for each dose). Sheep ingesting 5-40 g/kg bw were killed when moribund, 38-120 It after the start of the administration. Clinical signs and gross and histologic lesions were similar to those observed in field outbreak. The seeds used in the experiment contained 1.4% of monocrotaline. It is concluded that hungry sheep can be affected spontaneously by acute monocrotaline intoxication when they ingest large amounts of C. retusa seeds in a short period of time. (C) 2004 Elsevier Ltd. All rights reserved. |
英文关键词 | acute pyrrolizidine intoxication centrilobular necrosis Crotalaria retusa monocrotaline sheep |
类型 | Article |
语种 | 英语 |
国家 | Brazil |
收录类别 | SCI-E |
WOS记录号 | WOS:000227029800012 |
WOS关键词 | PYRROLIZIDINE ALKALOIDS ; TOXICITY ; LIVER |
WOS类目 | Pharmacology & Pharmacy ; Toxicology |
WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/150450 |
作者单位 | (1)Univ Fed Campina Grande, Dept Clin Vet, BR-58700000 Patos, Paraiba, Brazil;(2)Univ Fed Paraiba, Dept Tecnol Farmaceut, BR-58051970 Joao Pessoa, Paraiba, Brazil |
推荐引用方式 GB/T 7714 | Nobre, VMT,Dantas, AFM,Riet-Correa, F,et al. Acute intoxication by Crotalaria retusa in sheep[J],2005,45(3):347-352. |
APA | Nobre, VMT,Dantas, AFM,Riet-Correa, F,Barbosa, JM,Tabosa, IM,&Vasconcelos, JS.(2005).Acute intoxication by Crotalaria retusa in sheep.TOXICON,45(3),347-352. |
MLA | Nobre, VMT,et al."Acute intoxication by Crotalaria retusa in sheep".TOXICON 45.3(2005):347-352. |
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