Arid
DOI10.1016/j.toxicon.2004.11.005
Acute intoxication by Crotalaria retusa in sheep
Nobre, VMT; Dantas, AFM; Riet-Correa, F; Barbosa, JM; Tabosa, IM; Vasconcelos, JS
通讯作者Riet-Correa, F
来源期刊TOXICON
ISSN0041-0101
出版年2005
卷号45期号:3页码:347-352
英文摘要

Acute intoxication by seeding Crotalaria retusa occurred during the dry season, in a flock of 80 sheep, in the semi-arid region of the state of Paraiba, northeastern Brazil. Anorexia, severe depression, mild jaundice, incoordination and recumbence were observed in 16 sheep that died within 12 h. At necropsy the liver had a nutmeg appearance. Seeds of C. retusa were found in large amounts in the rumen of the dead animals. Histologic lesions of the liver were characterized by centrilobular necrosis. Seeds of C. retusa were given to six sheep at doses of 2.5 (two sheep), 5, 10, 20 and 40 g/kg bw (one sheep for each dose). Sheep ingesting 5-40 g/kg bw were killed when moribund, 38-120 It after the start of the administration. Clinical signs and gross and histologic lesions were similar to those observed in field outbreak. The seeds used in the experiment contained 1.4% of monocrotaline. It is concluded that hungry sheep can be affected spontaneously by acute monocrotaline intoxication when they ingest large amounts of C. retusa seeds in a short period of time. (C) 2004 Elsevier Ltd. All rights reserved.


英文关键词acute pyrrolizidine intoxication centrilobular necrosis Crotalaria retusa monocrotaline sheep
类型Article
语种英语
国家Brazil
收录类别SCI-E
WOS记录号WOS:000227029800012
WOS关键词PYRROLIZIDINE ALKALOIDS ; TOXICITY ; LIVER
WOS类目Pharmacology & Pharmacy ; Toxicology
WOS研究方向Pharmacology & Pharmacy ; Toxicology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/150450
作者单位(1)Univ Fed Campina Grande, Dept Clin Vet, BR-58700000 Patos, Paraiba, Brazil;(2)Univ Fed Paraiba, Dept Tecnol Farmaceut, BR-58051970 Joao Pessoa, Paraiba, Brazil
推荐引用方式
GB/T 7714
Nobre, VMT,Dantas, AFM,Riet-Correa, F,et al. Acute intoxication by Crotalaria retusa in sheep[J],2005,45(3):347-352.
APA Nobre, VMT,Dantas, AFM,Riet-Correa, F,Barbosa, JM,Tabosa, IM,&Vasconcelos, JS.(2005).Acute intoxication by Crotalaria retusa in sheep.TOXICON,45(3),347-352.
MLA Nobre, VMT,et al."Acute intoxication by Crotalaria retusa in sheep".TOXICON 45.3(2005):347-352.
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