Arid
DOI10.1126/science.1112014
The transcriptional landscape of the mammalian genome
Carninci, P; Kasukawa, T; Katayama, S; Gough, J; Frith, MC; Maeda, N; Oyama, R; Ravasi, T; Lenhard, B; Wells, C; Kodzius, R; Shimokawa, K; Bajic, VB; Brenner, SE; Batalov, S; Forrest, ARR; Zavolan, M; Davis, MJ; Wilming, LG; Aidinis, V; Allen, JE; Ambesi-Impiombato, X; Apweiler, R; Aturaliya, RN; Bailey, TL; Bansal, M; Baxter, L; Beisel, KW; Bersano, T; Bono, H; Chalk, AM; Chiu, KP; Choudhary, V; Christoffels, A; Clutterbuck, DR; Crowe, ML; Dalla, E; Dalrymple, BP; de Bono, B; Della Gatta, G; di Bernardo, D; Down, T; Engstrom, P; Fagiolini, M; Faulkner, G; Fletcher, CF; Fukushima, T; Furuno, M; Futaki, S; Gariboldi, M; Georgii-Hemming, P; Gingeras, TR; Gojobori, T; Green, RE; Gustincich, S; Harbers, M; Hayashi, Y; Hensch, TK; Hirokawa, N; Hill, D; Huminiecki, L; Iacono, M; Ikeo, K; Iwama, A; Ishikawa, T; Jakt, M; Kanapin, A; Katoh, M; Kawasawa, Y; Kelso, J; Kitamura, H; Kitano, H; Kollias, G; Krishnan, SPT; Kruger, A; Kummerfeld, SK; Kurochkin, IV; Lareau, LF; Lazarevic, D; Lipovich, L; Liu, J; Liuni, S; McWilliam, S; Babu, MM; Madera, M; Marchionni, L; Matsuda, H; Matsuzawa, S; Miki, H; Mignone, F; Miyake, S; Morris, K; Mottagui-Tabar, S; Mulder, N; Nakano, N; Nakauchi, H; Ng, P; Nilsson, R; Nishiguchi, S; Nishikawa, S; Nori, F; Ohara, O; Okazaki, Y; Orlando, V; Pang, KC; Pavan, WJ; Pavesi, G; Pesole, G; Petrovsky, N; Piazza, S; Reed, J; Reid, JF; Ring, BZ; Ringwald, M; Rost, B; Ruan, Y; Salzberg, SL; Sandelin, A; Schneider, C; Schonbach, C; Sekiguchi, K; Semple, CAM; Seno, S; Sessa, L; Sheng, Y; Shibata, Y; Shimada, H; Shimada, K; Silva, D; Sinclair, B; Sperling, S; Stupka, E; Sugiura, K; Sultana, R; Takenaka, Y; Taki, K; Tammoja, K; Tan, SL; Tang, S; Taylor, MS; Tegner, J; Teichmann, SA; Ueda, HR; van Nimwegen, E; Verardo, R; Wei, CL; Yagi, K; Yamanishi, H; Zabarovsky, E; Zhu, S; Zimmer, A; Hide, W; Bult, C; Grimmond, SM; Teasdale, RD; Liu, ET; Brusic, V; Quackenbush, J; Wahlestedt, C; Mattick, JS; Hume, DA; Kai, C; Sasaki, D; Tomaru, Y; Fukuda, S; Kanamori-Katayama, M; Suzuki, M; Aoki, J; Arakawa, T; Iida, J; Imamura, K; Itoh, M; Kato, T; Kawaji, H; Kawagashira, N; Kawashima, T; Kojima, M; Kondo, S; Konno, H; Nakano, K; Ninomiya, N; Nishio, T; Okada, M; Plessy, C; Shibata, K; Shiraki, T; Suzuki, S; Tagami, M; Waki, K; Watahiki, A; Okamura-Oho, Y; Suzuki, H; Kawai, J; Hayashizaki, Y
来源期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2005
卷号309期号:5740页码:1559-1563
英文摘要

This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5’ and 3’ boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.


类型Article
语种英语
收录类别SCI-E
WOS记录号WOS:000231715000049
WOS关键词GENE-EXPRESSION ; MOUSE ; IDENTIFICATION ; HUMAN-CHROMOSOME-21 ; ANNOTATION ; SEQUENCES ; ARRAYS ; RNAS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/150347
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Carninci, P,Kasukawa, T,Katayama, S,et al. The transcriptional landscape of the mammalian genome[J],2005,309(5740):1559-1563.
APA Carninci, P.,Kasukawa, T.,Katayama, S.,Gough, J.,Frith, MC.,...&Hayashizaki, Y.(2005).The transcriptional landscape of the mammalian genome.SCIENCE,309(5740),1559-1563.
MLA Carninci, P,et al."The transcriptional landscape of the mammalian genome".SCIENCE 309.5740(2005):1559-1563.
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